PSGL-1

P-Selectin Glycoprotein Ligand 1 (CLA, CD162, PSGL1, PSGL-1, SELPLG) is a SLe(x)-type proteoglycan and a high affinity binding partner expressed on all white blood cells, for the cell adhesion molecules P-, E- and L- selectin. PSGL-1 protein requires two distinct posttranslational modifications, tyrosine sulfation and the addition of the sialyl Lewis x tetrasaccharide (sLex) to its O-linked glycans, to gain its selectin binding activity. PSGL-1 plays a key role in the trafficking of leukocytes during the initial steps of inflammation by tethering of leukocytes to activated platelets or endothelia expressing P-selectin.

 

PSGL-1 Singleplex Products

Our PSGL-1 immunoassays provide fast, accurate, reproducible, and highly sensitive measurements of PSGL-1. MSD’s MULTI-ARRAY technology uses simple protocols, requires minimal sample, and quantifies analyte concentration over a wide dynamic range.

 

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