PSD-95

Postsynaptic density protein 95 (PSD-95), also known as SAP-90 (synapse-associated protein 90), belongs to a class of proteins referred to as MAGUKs (membrane-associated guanylate kinases). Canonical MAGUK proteins contain one or three PDZ (PSD-95/discs large/zona occludens-1) domains, an SH3 domain, and a guanylate kinase homology domain. PSD-95 and several other MAGUK and PDZ containing proteins (e.g., PSD-93, SAP-97, SAP-102, MALS/Veli proteins) are enriched in the post synaptic density. These proteins appear to regulate synaptic function by acting as molecular scaffolds for signaling machinery at synapses, in part by interaction of their PDZ domains with carboxy-terminal T/SXV motifs present on synaptic proteins including NMDA receptors and Shaker type K+ channels. PSD-95 has also been shown to link NMDA receptors to neuronal nitric oxide synthetase (nNOS), a downstream signal transduction protein, via a novel PDZ:PDZ interaction with nNOS. PSD-95 interacts with the cytoplasmic tail of NMDA receptor subunits and shaker-type potassium channels, which is important for synaptic plasticity associated with NMDA receptor signaling. Overexpression or depletion of PSD-95 changes the ratio of excitatory to inhibitory synapses in hippocampal neurons. PSD-95 has been linked to autism, drug addiction, learning, and memory. Phosphorylation is critical for the regulation of PSD-95 function.

 

PSD-95 Singleplex Products

Our PSD-95 immunoassays provide fast, accurate, reproducible, and highly sensitive measurements of PSD-95. MSD’s MULTI-ARRAY technology uses simple protocols, requires minimal sample, and quantifies analyte concentration over a wide dynamic range.

 

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