proMMP-9

proMatrix MetalloProteinase 9 (proMMP-9, GELB, CLG4B, MANDP2, 92kDa type IV collagenase) is a member of a family of endoproteinases, which are critically important in extracellular matrix remodeling. MMPs are highly homologous to each other and belong to a larger family of proteinases known as the metzincin superfamily. MMP-9 is a glycoprotein that plays a significant role in tissue remodeling, morphogenesis and cytokine activation. It degrades interstitial collagens, proteoglycan core protein, elastin, and type IV collagen in the basement membrane. MMP-9 can also cleave several non-matrix molecules such as IL-1β, IL-8, platelet factor-4, GRO-α, and amyloid β peptide. MMP-9 plays an important role in various disease processes, including cancer, rheumatoid arthritis, and atherosclerosis. MMP-9 is produced as a preproenzyme and secreted as an inactive proenzyme (proMMP-9) that is activated by extracellular proteinases including MMP-3. proMMP-9 can bind to TIMP-1, which protects it from being activated by MMP-3. The proMMP-9:TIMP-1 complex is able to inhibit other MMPs. proMMP-9 can also covalently bind to NGAL, which locks it in the inactive state.

 

proMMP-9 Singleplex Products

Our proMMP-9 immunoassays provide fast, accurate, reproducible, and highly sensitive measurements of proMMP-9. MSD’s MULTI-ARRAY technology uses simple protocols, requires minimal sample, and quantifies analyte concentration over a wide dynamic range.

 

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