PERK

Protein kinase-like endoplasmic reticulum kinase (PERK) is an endoplasmic reticulum (ER) transmembrane protein that mediates the unfolded protein response (UPR) adaptation to ER stressors. In response to the accumulation of misfolded proteins in the ER lumen, PERK is activated by oligomerization and autophosphorylation at threonine 981 in humans and threonine 980 in rats. Activated PERK phosphorylates eIF2α, resulting in global repression of translation and cell cycle arrest due to loss of the cyclin D1. Chronic PERK activation induces apoptosis and is associated with adverse conditions such as cancer, diabetes, muscle degeneration, and neurodegenerative diseases.

 

PERK Singleplex Products

Our PERK immunoassays provide fast, accurate, reproducible, and highly sensitive measurements of PERK. MSD’s MULTI-ARRAY technology uses simple protocols, requires minimal sample, and quantifies analyte concentration over a wide dynamic range.

 

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Related Custom Assays

The following related assays are not in our catalog but may be available as custom orders. Custom orders are typically shipped in 3 to 6 weeks. You may request pricing and availability for the assays below using our Custom Assay Quote Request form.

  • Phospho-PERK - Thr980 -
  • Phospho-PERK-Thr981 -
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