PD-L2

Programmed cell death ligand 2 (PD-L2, PDCD1LG2, CD273, B7-DC) is an immune inhibitory ligand that is expressed by hematopoietic and non-hematopoietic cells, such as T cells and B cells and various types of tumor cells. The protein is a type I transmembrane protein that has immunoglobulin V-like and C-like domains. Interaction of this ligand with its receptor inhibits T-cell activation and cytokine production. During infection or inflammation of normal tissue, this interaction is important for preventing autoimmunity by maintaining homeostasis of the immune response. In tumor microenvironments, this interaction provides an immune escape for tumor cells through cytotoxic T-cell inactivation. Constitutive basal expression of PD-L2 is lower than PD-L1. PD-L2 cross-competes with PD-L1 to bind to the receptor.

 

PD-L2 Singleplex Products

Our PD-L2 immunoassays provide fast, accurate, reproducible, and highly sensitive measurements of PD-L2. MSD’s MULTI-ARRAY technology uses simple protocols, requires minimal sample, and quantifies analyte concentration over a wide dynamic range.

 

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