p70S6K

The serine/threonine kinase p70S6K exists in two isoforms within the cell, a 70 kDa cytosolic protein, and an 85 kDa nuclear protein. The small ribosomal protein S6 (of the 40S subunit) is phosphorylated by active p70S6K on five serine residues. Activation of p70S6K is linked to the phosphorylation of several serine and threonine residues including threonines at positions 229, 389, and 421, and serines at positions 411 and 424. A diverse array of proteins have been shown to play a role in p70S6K activation including PDK1, the G proteins Cdc42 and Rac1, mTOR, and the c-Raf/MEK/ERK pathway. These effectors are activated upstream by insulin, amino acids, and growth factors. In response, p70S6K exerts an effect on translation initiation, cell cycle progression, and cell survival.

 

p70S6K Singleplex Products

Our p70S6K immunoassays provide fast, accurate, reproducible, and highly sensitive measurements of p70S6K. MSD’s MULTI-ARRAY technology uses simple protocols, requires minimal sample, and quantifies analyte concentration over a wide dynamic range.

 

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p70S6K Multiplex Products

Our multiplex panels let you process up to 10 analytes simultaneously in each well of a MULTI-SPOT microplate. They provide the same outstanding performance as our singleplex immmunoassays while saving money, sample, and time.

 

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Related Custom Assays

The following related assays are not in our catalog but may be available as custom orders. Custom orders are typically shipped in 3 to 6 weeks. You may request pricing and availability for the assays below using our Custom Assay Quote Request form.

  • Phospho-p70S6K (Thr389) -
  • Phospho-p70S6K (Thr421/Ser424) -
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