p38

The serine/threonine kinase p38, also known as RK, SAPK2A, and CSBP, is involved in mediating cellular responses to inflammatory cytokines and environmental stresses such as osmotic shock and UV light. Four isoforms (α, β, γ, δ) of p38 have currently been identified. Activation of p38 by phosphorylation of threonine 180 and tyrosine 182 is controlled by several upstream kinases including MKK3, MKK6, and MKK4 (SEK). Activated p38 in turn can phosphorylate MAPKAPK2, PRAK kinase, and the transcription factors ATF-2, MAX, CHOP, and MEF2. The p38 signaling pathway regulates various biological processes such as cytokine production, transcriptional regulation, cell proliferation and differentiation, and apoptosis

 

p38 Singleplex Products

Our p38 immunoassays provide fast, accurate, reproducible, and highly sensitive measurements of p38. MSD’s MULTI-ARRAY technology uses simple protocols, requires minimal sample, and quantifies analyte concentration over a wide dynamic range.

 

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p38 Multiplex Products

Our multiplex panels let you process up to 10 analytes simultaneously in each well of a MULTI-SPOT microplate. They provide the same outstanding performance as our singleplex immmunoassays while saving money, sample, and time.

 

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Related Custom Assays

The following related assays are not in our catalog but may be available as custom orders. Custom orders are typically shipped in 3 to 6 weeks. You may request pricing and availability for the assays below using our Custom Assay Quote Request form.

  • Phospho-p38 -
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