NT-proANP

N-terminal proatrial natriuretic peptide (NT-proANP) is the biologically inactive fragment (98 amino acid) of the ANP prohormone. The secreted prohormone is cleaved producing the N-terminus fragment (NT-proANP) and the atrial natruiretic peptide (ANP). The natriuretic peptides have a common characteristic biochemical structure that consists of a ring of 17 amino acids and a disulfide bridge between 2 cysteine molecules. NT-proANP has been shown to be a useful diagnostic and prognostic tool in heart failure and myocardial infarction. NT-proANP is more stable and has a longer half-life in circulation than ANP. In patients with mild to moderate cardiac disease, NT-proANP levels were increased in response to atrial wall stress increase. Patients diagnosed with diastolic or systolic dysfunction had 2- to 3-fold higher NT-proANP than the control group. A recent study in rat showed that NT-proANP is an excellent biomarker for cardiac hypertrophy.

 

NT-proANP Singleplex Products

Our NT-proANP immunoassays provide fast, accurate, reproducible, and highly sensitive measurements of NT-proANP. MSD’s MULTI-ARRAY technology uses simple protocols, requires minimal sample, and quantifies analyte concentration over a wide dynamic range.

 

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