MMP-9 (total)

Total Matrix Metalloproteinase 9 (MMP-9, GELB, CLG4B, MANDP2, 92kDa type IV collagenase) is a member of a family of endoproteinases that are critically important in extracellular matrix remodeling. MMPs are highly homologous to each other and belong to a larger family of proteinases known as the metzincin superfamily. MMP-9 is a glycoprotein that plays a significant role in tissue remodeling, morphogenesis and cytokine activation. It degrades interstitial collagens, proteoglycan core protein, elastin and type IV collagen in the basement membrane. MMP-9 can also cleave several non-matrix molecules such as IL-1β, IL-8, platelet factor-4, GRO-α, and amyloid β peptide. MMP-9 plays an important role in various disease processes, including cancer, rheumatoid arthritis and atherosclerosis. MMP-9 is produced as a preproenzyme and secreted as an inactive proenzyme (proMMP-9), which is activated by extracellular proteinases including MMP-3. Total MMP-9 includes both proMMP-9 and active forms of MMP-9.

 

MMP-9 (total) Singleplex Products

Our MMP-9 (total) immunoassays provide fast, accurate, reproducible, and highly sensitive measurements of MMP-9 (total). MSD’s MULTI-ARRAY technology uses simple protocols, requires minimal sample, and quantifies analyte concentration over a wide dynamic range.

 

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