Macrophage inflammatory protein 4 (MIP-4) (CCL18/PARC/AMAC-1/DC-CK-1/SCYA18) is a C-C chemokine strongly expressed in the lung and to a lesser extent in the thymus and lymph nodes. To date, the functional receptor and role of MIP-4 has been difficult to ascertain as it appears to exist only in primates, rendering rodent models unusable. MIP-1α is the most closely related chemokine to MIP-4, but CCR1 and CCR5 (of which MIP-1α is a ligand) do not bind MIP-4. In vitro, MIP-4 is particularly chemotactic for naive T-lymphocytes, Th2 cells, B cells, and immature dendritic cells. Despite MIP-4’s absence in rodents, it is functionally active in humans as a T-lymphocyte chemoattractant. Research implicates MIP-4 involvement in tumor malignancy and various inflammatory and allergic pulmonary, skin, and joint diseases. In chronic obstructive pulmonary disease, an elevated level of MIP-4 coincides with clinical outcome and can serve as a potential biomarker. MIP-4 is also expressed in abundance in tumor-associated macrophages found in breast tissue and is associated with increased breast cancer metastasis. MIP-4 is thought to cause increased ECM adherence of cancerous cells to fibronectin in the stroma allowing subsequent invasion.


MIP-4 Singleplex Products

Our MIP-4 immunoassays provide fast, accurate, reproducible, and highly sensitive measurements of MIP-4. MSD’s MULTI-ARRAY technology uses simple protocols, requires minimal sample, and quantifies analyte concentration over a wide dynamic range.


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