Met

c-Met, also known as the hepatocyte growth factor receptor, is a proto-oncogene with tyrosine kinase activity. Hepatocyte growth factor (HGF) is the only identified ligand for Met and upon ligand binding, the Met receptor dimerizes, autophosphorylates its catalytic residues, and prepares to bind adaptor proteins to continue signaling through downstream mediators. HGF activation of Met induces growth, proliferation, cell survival, motility, and angiogenesis. Met has a tyrosine kinase domain, containing phosphorylated residues Tyr1234 and Tyr1235, and a multi-substrate docking site, containing phosphorylated residues Tyr1349 and Tyr1356. Phosphorylation of these residues are key to the direct biological effects of Met activation as well as the ability of Met to signal through other downstream signaling cascades such as the PI3K signaling cascade, SRC, STAT, and Ras-Raf-Mek-Erk cascades. Due to the involvement of Met in so many different types of cancers, there has been a lot of research and drug development directed towards disruption and modulation of the HGF-Met interactions and the downstream signaling cascades controlled through Met-HGF binding.

 

Met Singleplex Products

Our Met immunoassays provide fast, accurate, reproducible, and highly sensitive measurements of Met. MSD’s MULTI-ARRAY technology uses simple protocols, requires minimal sample, and quantifies analyte concentration over a wide dynamic range.

 

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Met Multiplex Products

Our multiplex panels let you process up to 10 analytes simultaneously in each well of a MULTI-SPOT microplate. They provide the same outstanding performance as our singleplex immmunoassays while saving money, sample, and time.

 

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Related Custom Assays

The following related assays are not in our catalog but may be available as custom orders. Custom orders are typically shipped in 3 to 6 weeks. You may request pricing and availability for the assays below using our Custom Assay Quote Request form.

  • Phospho-Met -
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