MEK2

MEK1 and MEK2 (MAPK/ERK kinases 1 and 2), also known as MKK1 and MKK2, are dual-specificity kinases that function as part of the intracellular mitogen-activated protein kinase signaling cascade activated in response to cellular stimulation by cytokines and growth factors. At the cell membrane, receptor tyrosine kinases interact with the GTPase Ras through adaptor proteins, resulting in the phosphorylation of a MAPK kinase kinase (MAP3K), thereby activating the MAPK signaling pathway and resulting in a biological response. MEK1 and MEK2 are phosphorylated by the serine/threonine kinases Raf-1, Mos, and MEK kinase on serines 217 and 221. PDK1 has also been shown to phosphorylate MEK1 and MEK2, linking the PI-3 kinase /Akt signaling pathway with ERK activation. Activated MEK1 and MEK2 phosphorylate ERK1 /2 on threonine 202 and tyrosine 204 of ERK1 and threonine 185 and tyrosine 187 of ERK2. Activated ERK1/2 phosphorylate targets in both the nucleus and cytoplasm, exerting a regulatory effect on both transcription and translation. The activation of the Raf/MEK/ERK pathway has been shown to affect development, cell growth and differentiation, cell transformation, and cell cycle progression.

 

MEK2 Multiplex Products

Our multiplex panels let you process up to 10 analytes simultaneously in each well of a MULTI-SPOT microplate. They provide the same outstanding performance as our singleplex immmunoassays while saving money, sample, and time.

 

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