JNK

The c-Jun N-terminal kinase (JNK) family of kinases, also known as SAPK (stress-activated protein kinase) and MAPK8 (mitogen-activated protein kinase-8), are encoded by three genes (JNK 1-3) that produce more than 10 isoforms. Inflammatory cytokines and cellular stresses such as UV light and osmotic shock lead to JNK activation through the intercellular signaling cascade including Ras and Rac, MEKK1, and MKK4 or MKK7. JNK is fully activated by phosphorylation on threonine 183 and tyrosine 185 by MKK4 and MKK7. Activated JNK in turn phosphorylates the transcription factors c-Jun, ATF-2, and Elk-1, thereby regulating gene transcription. JNK is involved with the function of the mitochondrial apoptotic pathway, mediating the release of cytochrome c and the phosphorylation of Bim and Bmf. JNK also affects expression of many cytokine genes, as well as playing a role in tumor development, embryonic morphogenesis, and cell survival.

 

JNK Singleplex Products

Our JNK immunoassays provide fast, accurate, reproducible, and highly sensitive measurements of JNK. MSD’s MULTI-ARRAY technology uses simple protocols, requires minimal sample, and quantifies analyte concentration over a wide dynamic range.

 

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JNK Multiplex Products

Our multiplex panels let you process up to 10 analytes simultaneously in each well of a MULTI-SPOT microplate. They provide the same outstanding performance as our singleplex immmunoassays while saving money, sample, and time.

 

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Related Custom Assays

The following related assays are not in our catalog but may be available as custom orders. Custom orders are typically shipped in 3 to 6 weeks. You may request pricing and availability for the assays below using our Custom Assay Quote Request form.

  • Phospho-JNK -
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