IGF-1R

IGF-1R and IR belong to the family of tyrosine kinase receptors and are comprised of 2 alpha and 2 beta subunits which are connected via disulfide bonds. The alpha subunits are extracellular and the beta subunits are membrane spanning, intracellular, and responsible for the downstream signaling mediated by binding of the ligands: IGF-1, IGF-2, and insulin. Upon ligand binding, these receptors autophosphorylate on multiple tyrosine residues within the beta subunits. This autophosphorylation results in the binding of multiple docking and adaptor proteins (such as Shc and IRS-1/2) involved in signaling through the Ras/MAP kinase and AKT/PI3 kinase signaling cascades. IGF-1R signaling plays a key role in normal development, growth, metabolism, and cellular homeostasis and is implicated in disease processes such as growth abnormalities, metabolic processes, and different types of cancer. Pharmacological disruption of IGF-1R/IR signaling is a fertile area of research, but due a critical role in normal cellular metabolism and growth, the ability to identify selective therapeutics targeting abnormally signaling cells would be greatly advantageous.

 

IGF-1R Multiplex Products

Our multiplex panels let you process up to 10 analytes simultaneously in each well of a MULTI-SPOT microplate. They provide the same outstanding performance as our singleplex immmunoassays while saving money, sample, and time.

 

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Related Custom Assays

The following related assays are not in our catalog but may be available as custom orders. Custom orders are typically shipped in 3 to 6 weeks. You may request pricing and availability for the assays below using our Custom Assay Quote Request form.

  • IGF-1R - Human
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