HSP70

Heat Shock 70 kDa Proteins (HSP70) are a family of heat shock proteins encoded by 11 genes, many of which are inducible. HSP70s function as molecular chaperones, as they assist in folding and stabilization of newly and partially synthesized polypeptides to prevent aggregation before they are completely folded, assist in transmembrane transport of some proteins, prevent aggregation of partially denatured proteins due to thermal and oxidative stress, assist in degradation of damaged and defective proteins, and play a role in inhibiting apoptosis. HSP70s are of interest in cancer research because high levels of HSP70 expression have been associated with negative outcomes in breast, oral, colorectal, prostate, and endometrial cancers as well as some leukemias. The anti-apoptotic functions (both caspase-dependent and independent) of HSP70 may contribute to its role in cancer. HSP70s also appear to play a role in neurodegenerative diseases, such as Alzheimer’s disease, Parkinson’s disease, and Huntington’s disease, as accumulation of misfolded or aggregated proteins leads to cellular/neuronal destruction, a characteristic of these and other neurodegenerative diseases.

 

HSP70 Singleplex Products

Our HSP70 immunoassays provide fast, accurate, reproducible, and highly sensitive measurements of HSP70. MSD’s MULTI-ARRAY technology uses simple protocols, requires minimal sample, and quantifies analyte concentration over a wide dynamic range.

 

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