Histone H3

Histone H3, along with H2a, H2b, H1/H5, and H4, is one of the five main classes of histones, which are found in the nucleus of eukaryotic cells and are the main building blocks of chromatin. Histone H3 has an amino terminal tail, and post-translational modification of this tail, an epigenetic modification, is involved in chromatin relaxation and transcriptional regulation. Histones undergo many different types of post translational modifications, such as acetylation, methylation, phosphorylation, ubiquitylation, and sumoylation. These modifications can change the chromatin structure and allow for binding of transcription factors to the DNA. Acetylation of lysine residues on histones is frequently associated with actively transcribed regions of the genome, whereas methylation of lysine is seen both at transcribed and transcriptionally repressed areas of the genome. Epigenetic modifications, of which histone post-translational modification is one example, have been shown to play a role in cancer, embryonic stem cell function, and mammalian development.

 

Histone H3 Singleplex Products

Our Histone H3 immunoassays provide fast, accurate, reproducible, and highly sensitive measurements of Histone H3. MSD’s MULTI-ARRAY technology uses simple protocols, requires minimal sample, and quantifies analyte concentration over a wide dynamic range.

 

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