GSK-3α

Glycogen synthase kinase-3 (GSK-3) is a serine/threonine protein kinase that is found in two cellular isoforms; -α and -β. GSK-3 has diverse cellular effects, including involvement in metabolism, embryonic development, and cell survival. The two isoforms are regulated through phosphorylation, with inhibition as a result of growth factor and insulin-mediated phosphorylation by Akt on Ser 21 (GSK-3α) and Ser 9 (GSK-3β). The inhibition of GSK-3α/GSK-3β results in the dephosphorylation and activation of substrates such as glycogen synthase, elF-2B, and C/EBPα causing increased protein and glycogen synthesis. Tyrosine (216) phosphorylation of GSK-3β results in its activation and the subsequent phosphorylation of various cellular proteins including cyclin D-1 and β-catenin. An important member of the Wnt signaling pathway, GSK-3 plays a role in cell fate in early embryonic development. GSK-3β has also been implicated in the progression of Alzheimer’s disease through the phosphorylation of the microtubule-associated protein tau.

 

GSK-3α Singleplex Products

Our GSK-3α immunoassays provide fast, accurate, reproducible, and highly sensitive measurements of GSK-3α. MSD’s MULTI-ARRAY technology uses simple protocols, requires minimal sample, and quantifies analyte concentration over a wide dynamic range.

 

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Related Custom Assays

The following related assays are not in our catalog but may be available as custom orders. Custom orders are typically shipped in 3 to 6 weeks. You may request pricing and availability for the assays below using our Custom Assay Quote Request form.

  • GSK-3α total - Human
  • Phospho-GSK-3α -
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