gp130 (soluble)

Soluble glycoprotein 130 (soluble gp130, CD130, CDw130, IL-6RB, IL6ST) is a secreted version of gp130. Membrane bound gp130 is a vital protein that supports transmembrane signaling of IL-6, IL-11, IL-27, CT-1, CNTF, LIF, and OSM by binding to ligand/receptor complexes followed by dimerization into a 6-mer. It is present on most cell types, depending on their activation state. Soluble gp130 may be produced by cleavage of the extracellular domain of the membrane version of gp130, or by translation of truncated splice variants, and acts as an inhibitor of classic IL-6 activity.


gp130 (soluble) Singleplex Products

Our gp130 (soluble) immunoassays provide fast, accurate, reproducible, and highly sensitive measurements of gp130 (soluble). MSD’s MULTI-ARRAY technology uses simple protocols, requires minimal sample, and quantifies analyte concentration over a wide dynamic range.


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