FRS2

Fibroblast growth factor receptor substrate 2 (FRS2)—also known as suc-associated, neurotrophic factor-induced, tyrosine-phosphorylated target (SNT)—is an adaptor protein involved in linking the fibroblast and nerve growth factor receptors with the RAS/MAPK signaling pathways. The FRS2 family is comprised of two members, FRS2-α and FRS2-β. Both are composed of an amino terminal myristoylation signal, a phosphotyrosine binding domain, and a carboxy-terminal tail containing adaptor protein binding domains. Within this carboxy terminal tail are two phosphorylation sites: tyrosine 436, which recruits SHP-2 signaling proteins and tyrosine 196, which interacts with GRB-SOS signaling complexes. The phosphotyrosine binding domains of FRS2-α and β interact directly with fibroblast and nerve growth factor receptors in both a phosphorylation-dependent and -independent manner. When the FGF receptor binds ligand, it autophosphorylates; this in turn leads to FRS2 binding and subsequent phosphorylation and recruitment of SHP2 and GRB2. This complex binds GAB1, activates PI3K, and converts PIP2 to PIP3 resulting in AKT translocation to the plasma membrane and subsequent downstream signaling through GSK-3β, FOX01, and FOX03. The FGF/FGF receptor signaling cascade is believed to play a role in many different types of human cancers, and drugs to modulate this signaling cascade are an active area of pharmaceutical research.

 

FRS2 Singleplex Products

Our FRS2 immunoassays provide fast, accurate, reproducible, and highly sensitive measurements of FRS2. MSD’s MULTI-ARRAY technology uses simple protocols, requires minimal sample, and quantifies analyte concentration over a wide dynamic range.

 

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Related Custom Assays

The following related assays are not in our catalog but may be available as custom orders. Custom orders are typically shipped in 3 to 6 weeks. You may request pricing and availability for the assays below using our Custom Assay Quote Request form.

  • Phospho-FRS2 -
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