Fractalkine

Fractalkine (CX3CL1) is a multi-functional, transmembrane protein with an extracellular, chemokine domain that sits atop a mucin-like stalk which aids in the binding of certain immune cells. The transmembrane form can be proteolytically processed to generate a secreted 90 kDa soluble form. Soluble fractalkine has been observed in serum, urine, CSF, and synovial fluids. The soluble form acts as a chemoattractant for monocytes, natural killer (NK) cells, and lymphocytes. Fractalkine is thought to mediate interactions between neurons and microglia in the brain, and protects the brain against reactive oxygen species during neuroinflammation. The membrane-bound form is predominantly expressed on vascular endothelium, smooth muscle, neurons and epithelial linings of the intestine, bronchi, and renal proximal tubules. At these surfaces, TNF-α, IFN-γ, and IL-1 promote increased fractalkine expression and subsequent adhesion of leukocytes and extracellular matrix proteins to the inflamed endothelial cells. Thus, fractalkine is involved in the pathogenesis of various clinical disease states or processes, such as atherosclerosis, glomerulonephritis, renal and cardiac allograft rejection, and rheumatoid arthritis.

 

Fractalkine Singleplex Products

Our Fractalkine immunoassays provide fast, accurate, reproducible, and highly sensitive measurements of Fractalkine. MSD’s MULTI-ARRAY technology uses simple protocols, requires minimal sample, and quantifies analyte concentration over a wide dynamic range.

 

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Fractalkine Multiplex Products

Our multiplex panels let you process up to 10 analytes simultaneously in each well of a MULTI-SPOT microplate. They provide the same outstanding performance as our singleplex immmunoassays while saving money, sample, and time.

 

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