FOXO3a

Forkhead box O3a (FOXO3a) belongs to the O subclass of the forkhead family of transcription factors (FOXO1, FOXO3a, FOXO4, FOXO6) which are characterized by a forkhead DNA binding domain. This transcription factor regulates multiple transcriptional targets involved in various cellular processes, including proliferation, stress resistance, apoptosis, metabolism, and longevity. As a transcription factor, FOXO3a plays a key role in cellular senescence through regulation of genes promoting cell cycle arrest and apoptosis. Increased proliferation results when FOXO3a is inactivated through phosphorylation by Akt or PI3K at threonine 32, serine 253, and serine 315. This results in nuclear export and inhibition of transcription factor activity. Other post-translational modifications, including acetylation, methylation, or interactions with reactive oxygen species (ROS), may also result in increased or abnormal FOXO3a activity. Therefore, phosphorylation of FOXO3a is often associated with tumorigenesis and cancer development. A better understanding of the regulation of FOXO3a activity and its specific transcriptional targets may provide strong insight into the mechanisms controlling cell fate decisions.

 

FOXO3a Singleplex Products

Our FOXO3a immunoassays provide fast, accurate, reproducible, and highly sensitive measurements of FOXO3a. MSD’s MULTI-ARRAY technology uses simple protocols, requires minimal sample, and quantifies analyte concentration over a wide dynamic range.

 

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Related Custom Assays

The following related assays are not in our catalog but may be available as custom orders. Custom orders are typically shipped in 3 to 6 weeks. You may request pricing and availability for the assays below using our Custom Assay Quote Request form.

  • Phospho-FOXO3a -
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