eIF4E

Eukaryotic translation initiation factor 4E (eIF4E) is a polypeptide which binds to the 7-methyl guanosine (m7G) 5’ end of the mRNA cap structure and directs its association with ribosomes, initiating eukaryotic protein synthesis. A pleiotropic regulator of translation, eIF4E enables the expression of key genes—such as cyclins, c-myc, and vascular endothelial growth factor (VEGF)— involved in cell proliferation, angiogenesis, and cell survival. Overexpression of eIF4E phosphorylated at serine 209 is associated with tumorigenesis, metastasis, recurrence, and poor overall survival in several cancers, including breast, colon, lung, prostate, breast, lymphoid. As transformed or malignant cells have larger requirements for the expression of pro-survival factors, targeting eIF4E translation and its associated phosphorylation pathways remains an attractive anticancer strategy.

 

eIF4E Singleplex Products

Our eIF4E immunoassays provide fast, accurate, reproducible, and highly sensitive measurements of eIF4E. MSD’s MULTI-ARRAY technology uses simple protocols, requires minimal sample, and quantifies analyte concentration over a wide dynamic range.

 

View All
Related Custom Assays

The following related assays are not in our catalog but may be available as custom orders. Custom orders are typically shipped in 3 to 6 weeks. You may request pricing and availability for the assays below using our Custom Assay Quote Request form.

  • Phospho-eIF4E -
Browse Our Products

By Analytes
By Applications
Search
Customer Service/Orders


Scientific/Technical Support


Instrument Support


Company Headquarters