DJ-1/PARK7

The DJ-1/PARK7 gene is linked to familial early-onset Parkinson’s disease (PD) and encodes a 189 amino acid protein belonging to the DJ-1/Thi/PfpI superfamily of proteins. DJ-1/PARK7 has been implicated as an oxidative stress sensor that functions to promote the survival of dopaminergic neurons. Under oxidative conditions, DJ-1/PARK7 undergoes a pI shift from 6.2 to 5.8 and protects against mitochondrial damage. DJ-1/PARK7 also functions as a redox-dependent protein chaperone to suppress aggregation of α-synuclein, the main constituent in Lewy bodies prominent in the brains of PD patients. Furthermore, DJ-1/PARK7 forms a complex with parkin and PTEN-induced putative kinase 1 (PINK1) during oxidative stress to promote the degradation of parkin substrates, many of which have been implicated in neurodegeneration.

 

DJ-1/PARK7 Singleplex Products

Our DJ-1/PARK7 immunoassays provide fast, accurate, reproducible, and highly sensitive measurements of DJ-1/PARK7. MSD’s MULTI-ARRAY technology uses simple protocols, requires minimal sample, and quantifies analyte concentration over a wide dynamic range.

 

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