CTLA-4

Cytotoxic T-lymphocyte associated protein 4 (CTLA-4, ALPS5, CD152) is a member of the immunoglobulin superfamily and encodes a protein receptor that acts as an immune checkpoint and can transmit an inhibitory signal to T cells when bound by CD80 or CD86. The protein contains a V domain, a transmembrane domain, and a cytoplasmic tail. The membrane-bound isoform functions as a homodimer interconnected by a disulfide bond, while the soluble isoform functions as a monomer. Blocking CTLA-4 and CD80/86 interaction augments antitumor T cell activity. Mutations in this gene have been associated with insulin-dependent diabetes mellitus, Graves disease, Hashimoto thyroiditis, celiac disease, systemic lupus erythematosus, thyroid-associated orbitopathy, and other autoimmune diseases.

 

CTLA-4 Singleplex Products

Our CTLA-4 immunoassays provide fast, accurate, reproducible, and highly sensitive measurements of CTLA-4. MSD’s MULTI-ARRAY technology uses simple protocols, requires minimal sample, and quantifies analyte concentration over a wide dynamic range.

 

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