c-Jun

c-Jun is a proto-oncogene encoding for proteins that either homodimerize or heterodimerize with members of the c-Fos protein family to form the transcription factor activator protein-1 (AP-1). Activation of transcription through c-Jun is mediated by SAPK/JNK. In response to cellular exposure to growth factors, cytokines, cellular stress, or damaging agents, upstream phosphorylation events in the MAPK pathway result in the phosphorylation of SAPK/JNK. SAPK/JNK binds to c- Jun on its delta domain and phosphorylates it on serines 63 and 73, located in its transactivation domain. Both the delta and transactivation domains of c-Jun are located near the N-terminus, whereas the DNA-binding and dimerization domains are located near the C-terminus of the protein. The dimerization domain contains a leucine zipper motif which mediates the formation of homo- and heterodimers with Jun and Fos proteins to form AP-1. The AP-1 transcription factor complex binds to TPA response elements on DNA and regulates the expression of genes involved in cellular growth, signaling, differentiation, and apoptosis.

 

c-Jun Singleplex Products

Our c-Jun immunoassays provide fast, accurate, reproducible, and highly sensitive measurements of c-Jun. MSD’s MULTI-ARRAY technology uses simple protocols, requires minimal sample, and quantifies analyte concentration over a wide dynamic range.

 

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Related Custom Assays

The following related assays are not in our catalog but may be available as custom orders. Custom orders are typically shipped in 3 to 6 weeks. You may request pricing and availability for the assays below using our Custom Assay Quote Request form.

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