Brain natriuretic peptide (BNP), also known as B-type natriuretic peptide or GC-B, was first isolated from the porcine brain and contains either 26 (BNP-26) or 32 (BNP-32) amino acid residues. In contrast, human and rat BNPs are produced mostly in the heart and the predominant circulating forms consist of 32 and 45 (BNP-45) amino acids respectively. BNP mRNA is not detected in the rat brain, whereas it can be detected in the human brain. Thus, there is a substantial difference in the distribution and processing of BNP in different species. Studies have indicated that the levels of BNP are elevated in the plasma of patients with congestive heart failure. The measurement of BNP levels can be used in primary care for accurate and rapid diagnosis of heart failure, and for risk stratification of patients suffering from heart attack in emergency care. BNP is also used to assess the effectiveness of treatment for heart failure.


BNP Singleplex Products

Our BNP immunoassays provide fast, accurate, reproducible, and highly sensitive measurements of BNP. MSD’s MULTI-ARRAY technology uses simple protocols, requires minimal sample, and quantifies analyte concentration over a wide dynamic range.


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