APP

The characteristic beta amyloid plaques observed in Alzheimer’s Disease are produced by the processing of amyloid precursor protein (APP) into multiple protein fragments. The extracellular protein, sAPPα is released upon APP cleavage by α-secretase, which precludes formation of the Aβ peptides and amyloid plaques, as the cleavage site lies within the Aβ peptide sequence. sAPPβ is the extracellular protein released upon APP cleavage by β-secretase, and the remaining fragment of APP, C99, is cleaved by γ-secretase to form the Aβ peptides. The Swedish variant of APP is cleaved by β-secretase for form sAPPβ sw, and contains a two amino acid substitution (APP 670-671) which renders it more likely to undergo β-secretase cleavage than the wild type protein and results in increased production of the amylyoidogenic Aβ peptides.

 

APP Singleplex Products

Our APP immunoassays provide fast, accurate, reproducible, and highly sensitive measurements of APP. MSD’s MULTI-ARRAY technology uses simple protocols, requires minimal sample, and quantifies analyte concentration over a wide dynamic range.

 

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APP Multiplex Products

Our multiplex panels let you process up to 10 analytes simultaneously in each well of a MULTI-SPOT microplate. They provide the same outstanding performance as our singleplex immmunoassays while saving money, sample, and time.

 

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Related Custom Assays

The following related assays are not in our catalog but may be available as custom orders. Custom orders are typically shipped in 3 to 6 weeks. You may request pricing and availability for the assays below using our Custom Assay Quote Request form.

  • APPβ - Mouse, Rat
  • sAPPa -
  • SW sAPP-beta -
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