α-Synuclein

Alpha-synuclein is a 140 amino acid protein abundantly expressed in the nervous system and genetically linked to Parkinson’s disease (PD). It is thought to maintain synaptic integrity and normal cellular homeostasis through synaptic vesicle recycling and neurotransmitter release modulation. While native α-synuclein is unfolded, it has a propensity to form toxic soluble oligomers (i.e., protofibrils) that ultimately aggregate into insoluble fibrils termed Lewy bodies (LBs). Aberrant α-synuclein pathology is prevalent among neurological samples from patients with α-synuclein-related conditions, commonly referred to as “synucleinopathies.” These disorders include PD, dementia with LBs (DLB), and multiple-system atrophy (MSA).

 

α-Synuclein Singleplex Products

Our α-Synuclein immunoassays provide fast, accurate, reproducible, and highly sensitive measurements of α-Synuclein. MSD’s MULTI-ARRAY technology uses simple protocols, requires minimal sample, and quantifies analyte concentration over a wide dynamic range.

 

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