Alpha-2-macroglobulin (A2M, Alpha-2-M, CPAMD5) is the largest non-immunoglobulin protein present in plasma and a major representative of the alpha-macroglobulin family, which includes complement proteins C3 and C4 as well as pregnancy zone protein (PZP). A2M is synthesized by macrophages, fibroblasts, and adrenocortical cells, but plasma A2M levels are mainly determined by liver synthesis. A2M is a 720 kDa protein composed of four identical 180 kDa subunits, each with 5 different reactive sites. A2M functions as an antiproteinase by inhibiting all four classes of proteinases (including serine-, cysteine-, aspartic- and metalloproteinases). Due to this ability, A2M functions as an inhibitor of fibrinolysis and coagulation via plasmin/kallikrein and thrombin, respectively. In addition, A2M binds to many cytokines and growth factors including platelet-derived growth factor, basic fibroblast growth factor, transforming growth factor-β, insulin, and IL-1β. Elevated plasma A2M levels are indicative of kidney failure. A2M also associates with amyloid-beta in the brain and so is of interest in research on Alzheimer’s disease.


A2M Singleplex Products

Our A2M immunoassays provide fast, accurate, reproducible, and highly sensitive measurements of A2M. MSD’s MULTI-ARRAY technology uses simple protocols, requires minimal sample, and quantifies analyte concentration over a wide dynamic range.


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A2M Multiplex Products

Our multiplex panels let you process up to 10 analytes simultaneously in each well of a MULTI-SPOT microplate. They provide the same outstanding performance as our singleplex immmunoassays while saving money, sample, and time.


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