V-PLEX Plus NHP IL-10 Kit

Interleukin-10 (IL-10), also known as cytokine synthesis inhibitory factor (CSIF), is a glycosylated homodimeric cytokine with two disulfide bonds. The homodimer binds to two IL-10 Rα subunits resulting in recruitment of two IL-10 Rβ chains to initiate the IL-10 mediated signal cascades. IL-10 Rβ is also associated with receptors of IL-22, IL-26, IL-28, and IL-29. IL-10 inhibits the synthesis of numerous cytokines (including IFN-γ, IL-2, IL-3, TNF-α, TNF-β, and GM-CSF) that suppress Th1 proinflammatory responses and promote phagocytic uptake. IL-10 has been shown to prevent liver necrosis during parasitic infection in mice.The NHP IL-10 Kit provides the assay-specific components for the quantitative determination of endogenous IL-10 in non-human primate urine, serum, plasma, and cell culture supernatants.

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25 plates
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