V-PLEX Plus Mouse IL-17A/F Kit


V-PLEX Plus Mouse IL-17A/F Kit Overview
The V-PLEX Plus Mouse IL-17A/F Kit is optimized for long-term and multi-site biomarker studies that require reliable, reproducible results with lot-to-lot consistency. The V-PLEX Plus Mouse IL-17A/F Kit enables the sensitive detection of native IL-17A/F in multiple sample types including serum, plasma, urine, cell culture supernatants, and PBMCs. To learn more about the advantages of V-PLEX assays click here.
The V-PLEX Plus Mouse IL-17A/F assay is also available in a multiplex combination with other related cytokines in the V-PLEX Cytokine Panel 1 (mouse) Kit (catalog # K15245G, K15245D).
All V-PLEX kits come with coated plates, calibrators, labeled detection antibodies, optimized diluents, a comprehensive product insert, and a certificate of analysis. V-PLEX Plus kits also include controls, wash buffer, and plate seals for added quality and convenience.

V-PLEX Plus Mouse IL-17A/F Assay Features
  • Validated to measure mouse IL-17A/F in serum, plasma, cell culture supernatants, PBMCs, and urine
  • Dynamic range: 0.231 pg/mL – 1,620 pg/mL
  • LLOQ: 1.39 pg/mL

Typical Data
Calibration curve accuracy and precision for the V-PLEX Plus Mouse IL-17A/F assay were assessed and representative data are presented below.

Figure 1. V-PLEX Plus Mouse IL-17A/F Calibration Curve
Mouse IL-17A/F Calibrator Curve
Figure 2. V-PLEX Plus Mouse IL-17A/F Data
Mouse IL-17A/F Calibrator Curve Data
IL-17A/F Analyte

Description - Mouse interleukin-17A/F heterodimer (IL-17A/F) is a cross-linked heterodimer composed of IL-17A (CTLA8; Gene ID: 16171) and IL-17F (CANDF6, ML1; Gene ID: 257630) proteins that is secreted by IL-23 activated Th17 cells. Activity is mediated by binding its receptor, a heterodimer of IL-17RA and IL-17RC expressed on multiple cell types including fibroblasts, which results in the activation of the Erk1/2 and NF-κB pathways. IL-17A/F signally responses have similar but intermediate potency between IL- 17A/A and IL-17F/F homodimers. Elevated expression is associated with corticosteroid-resistant ‘neutrophilic’ asthma, bacterial infections, and autoimmune diseases.

Disease Focus - Autoimmune and inflammatory diseases including asthma, rheumatoid arthritis, and inflammatory bowel disease (IBD).

Application Area - Inflammation, cytokines, and chemokines

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25 plates
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