V-PLEX Plus Human VEGF Kit


Human vascular endothelial factor (VEGF), also known as vascular permeability factor (VPF), is a glycosylated 22.3 kDa protein with five disulfide bonds. This growth factor plays a crucial role in angiogenesis, vasculogenesis, and endothelial cell growth. It induces endothelial cell proliferation, promotes cell migration, inhibits apoptosis, and induces permeabilization of blood vessels. The receptors of this analyte are VEGFR1 and VEGFR2; it also binds to heparin and neutropilin-1. It occurs as a disulfide-linked homodimer and as a heterodimer with PGF. There are numerous naturally occurring isoforms of VEGF. VEGF levels are associated with diabetes, renal cell carcinoma, and acute renal allograft rejection along with other disorders. The Human VEGF Kit provides assay-specific components for the quantitative determination of endogenous VEGF in human urine, serum, plasma, and cell culture supernatants.

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25 plates
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