V-PLEX Mouse IL-27p28/IL-30 Kit


V-PLEX Mouse IL-27p28/IL-30 Kit Overview
The V-PLEX Mouse IL-27p28/IL-30 Kit is optimized for long-term and multi-site biomarker studies that require reliable, reproducible results with lot-to-lot consistency. The V-PLEX Mouse IL-27p28/IL-30 Kit enables the sensitive detection of native IL-27p28/IL-30 in multiple sample types including serum, plasma, urine, cell culture supernatants, and PBMCs. To learn more about the advantages of V-PLEX assays click here.
The V-PLEX Mouse IL-27p28/IL-30 assay is also available in a multiplex combination with other related cytokines in the V-PLEX Cytokine Panel 1 (mouse) Kit (catalog # K15245G, K15245D).

V-PLEX Mouse IL-27p28/IL-30 Assay Features
  • Validated to measure mouse IL-27p28/IL-30 in serum, plasma, cell culture supernatants, PBMCs, and urine
  • Dynamic range: 1.39 pg/mL – 6,500 pg/mL
  • LLOQ: 5.91 pg/mL

Typical Data
Calibration curve accuracy and precision for the V-PLEX Mouse IL-27p28/IL-30 assay were assessed and representative data are presented below.

Figure 1. Mouse IL-27p28/IL-30 Calibration Curve
Mouse IL-27p28/IL-30 Calibrator Curve
Figure 2. Mouse IL-27p28/IL-30 Data
Mouse IL-27p28/IL-30 Calibrator Curve Data
IL-27p28/IL-30 Analyte

Description - Mouse interleukin-27p28 (IL-30) is one monomer that makes up IL-27, the other being the soluble receptor EBI3 (Epstein-Barr virus induced gene 3). p28 is homologically similar to CLC (cardiotrophin-like cytokine), and can dimerize with CLF (cytokine like factor 1). Both heterodimers (p28-EBI3, p28-CLF) are secreted by dendritic cells and macrophages and act on NK cells, mast cells, monocytes, and cytotoxic T cells through the IL-27R receptor which is composed of WSX-1 and gp130, as well as through IL-6R and gp130. p28 expression is upregulated by inflammatory stimuli; the resulting biological effects depend on which binding partner is expressed and which receptor is engaged.

Disease Focus - Rheumatoid arthritis, juvenile idiopathic arthritis, Castelman's disease, and multiple myeloma.

Application Area - Inflammation, cytokines, and chemokines

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