MSD offers a range of individual assays utilizing U-PLEX Antibody Sets that provide a rapid and convenient method for measuring biomarkers in complex matrices. The individual assays are offered on MSD GOLD Small Spot Streptavidin Plates and use the same antibody sets and diluents as the U-PLEX multiplex assays. This allows for efficient transfer between the individual assay and a higher throughput multiplex configuration. Typical of assays developed on the MSD platform, the individual assays have high sensitivity, excellent precision, provide up to five-logs of linear dynamic range, and require minimal sample volume. Vascular Endothelial Growth Factor-A (VEGF-A), also known as Vascular Permeability Factor (VPF) is a glycosylated protein with five disulfide bonds. VEGF-A plays a crucial role in angiogenesis, vasculogenesis, and endothelial cell growth. VEGF-A induces endothelial cell proliferation, promotes cell migration, inhibits apoptosis, and induces permeabilization of blood vessels. VEGF-A binds to VEGFR1 and VEGFR2 receptors as well as to heparin and Neutropilin-1. There are numerous naturally occurring isoforms to VEGF-A. Its levels are associated with diabetes, renal cell carcinoma, and acute renal allograft rejection, along with other disorders. The U-PLEX NHP VEGF-A Assay provides the components for the quantitative determination of both natural and recombinant VEGF-A in Cynomolgus monkey and Rhesus monkey serum, plasma, and cell culture supernatants.

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