U-PLEX Mouse IL-31 Assay


U-PLEX Mouse IL-31 Assay Overview
The U-PLEX Mouse IL-31 Assay maximizes your flexibility to design an experiment that measures IL-31 alone or multiplexed with MSD U-PLEX assays, your own antibody pairs, or a combination of both. U-PLEX assays demonstrate high sensitivity, excellent precision, and up to 5-logs of linear dynamic range. Plates are read in less than 90 seconds on any MSD instrument, using no complicated fluidics or calibration procedures.

U-PLEX Mouse IL-31 Assay Features
  • Simple protocol similar to ELISAs, yet uses less sample
  • Measures mouse IL-31 in serum, plasma, and cell culture supernatants
  • Create custom multiplexes using a selection of U-PLEX assays, your own antibody pairs or both

Assay Format
  • Singleplex – includes MSD GOLD Small Spot Streptavidin Plates
  • Multiplex – includes U-PLEX multiplex plates
  • Both formats use the same assay components for efficient transfer between single- and multiplex configurations.

IL-31 Analyte
Description- Mouse IL-31 is expressed primarily by TH2 cells and signals through a heterodimeric receptor consisting of GPL (GP130-like) and OSMRβ (oncostatin M receptor β) though it binds directly to the GPL protein. This receptor is found on keratinocytes and IFNγ-activated monocytes. IL-31 participates in atopic dermatitis and inflammatory bowel disease as a powerful proinflammatory cytokine. IL-31 elevates the expression of EGF, VEGF, and MCP-1, and activates MAPK protein, which induces bronchial inflammation.

Disease Focus - Autoimmunity, including atopic dermatitis, airway hypersensitivity, and irritable bowel disease.

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Price in USD
1 plate
5 plates
25 plates
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