R-PLEX Human Nectin-4 Antibody Set

R-PLEX Human Nectin-4 Antibody Set Overview
The R-PLEX Human Nectin-4 Antibody Set includes a matched capture and detection antibody pair and calibrator for the quick and easy measurement of Nectin-4 in biological samples. R-PLEX products leverage MSD’s electrochemiluminescence technology for better sensitivity and a larger dynamic range than traditional ELISAs. R-PLEX matched antibody sets enable the development of singleplex and multiplex immunoassays. Individual assays may be developed using MSD avidin- or streptavidin-coated plates. Custom multiplex assays with any combination of R-PLEX analytes, as well as R-PLEX plus U-PLEX analytes can be developed on U-PLEX MULTI-SPOT plates. To learn more about the advantages of R-PLEX products click here.

R-PLEX Human Nectin-4 Antibody Set Features
  • Measures human Nectin-4 in serum, plasma, and urine
  • Dynamic range: 1.5 - 10,000 pg/mL
  • Median LLOD: 1.5 pg/mL
  • Can be used to develop individual analyte assays as well as multiplex panels

Typical Data
Calibration curve for the R-PLEX Human Nectin-4 Antibody Set was assessed and representative data is presented below.

Figure 1. R-PLEX Human Nectin-4 Antibody Set Calibration Curve
Calibration curve for R-PLEX Human Nectin-4 Antibody Set

Nectin-4 Analyte

Description - Nectin-4 (PRR4, LNIR) is a type I transmembrane protein that can be cleaved by metalloproteinase to release a soluble portion of the protein that has been found in breast and ovarian cancers. Nectin-4 is part of the Nectin family of cell adhesion molecules, a subset of the Immunoglobulin superfamily. Nectin-4 overexpression is seen in endothelial cancers and recent research indicates that Nectin-4 is involved in breast and ovarian cancers and may have utility as both a biomarker and therapeutic target.

Disease Research Area - Cancer

Application Area - Infectious Disease

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50 plate size
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