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The R-PLEX platform offers matched sets of antibodies and calibrators for a wide menu of biomarkers. The R-PLEX Human IGF-1R Antibody Set can be used with other MSD components (see "Recommended Components" tab below) to build assays that measure IGF-1R. These assays can measure IGF-1R alone or in multiplex panels with other biomarkers.
The Product Inserts for R-PLEX Antibody Sets provide detailed instructions for building assays in several formats. The Datasheet for IGF-1R provides lot-specific information for the components (including calibrator stock concentrations), recommended sample types and dilution factors, and representative data for analytical performance. These items and other helpful documents can be found in the "Documentation" tab below.
Related Key Terms
insulin-like growth factor receptor 1, CD221, IGFR, JTK13, mitogen, cancer
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Specifications
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Recommended Components
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Documentation
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References
Application(s)
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Oncology & Cancer
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Metabolic
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Analyte(s)
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IGF-1R
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Species
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Human
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Usage Statement
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For Research Use Only. Not for use in diagnostic procedures.
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Storage Statement(s)
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Antibody set (2-8°C); Calibrator (≤-70°C)
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Gene ID(s)
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3480
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UniProt ID(s)
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P08069
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Why do I need other components
Catalog No.
Product Name
Size
R60AM-1
L45SA-1
Product Inserts
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Handouts
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SDS
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Title
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Journal
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Year
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Targeting IGF-IR with ganitumab inhibits tumorigenesis and increases durability of response to androgen-deprivation therapy in VCaP prostate cancer xenografts.
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Dependence of Wilms tumor cells on signaling through insulin-like growth factor 1 in an orthotopic xenograft model targetable by specific receptor inhibition.
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Dual IGF-I/II-Neutralizing Antibody MEDI-573 Potently Inhibits IGF Signaling and Tumor Growth.
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Efficacy of Ganitumab (AMG 479), Alone and in Combination With Rapamycin, in Ewing's and Osteogenic Sarcoma Models.
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Chronic treatment with epoxyeicosatrienoic acids modulates insulin signaling and prevents insulin resistance in hepatocytes.
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