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Phospho (Thr421/Ser424)/Total p70S6K Whole Cell Lysate Kit 5

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Phospho(Thr421/Ser424)/Total p70S6K Whole Cell Lysate Kit provides assay-specific components for the quantitative determination of phospho-p70S6K (Thr421/Ser424) and total p70S6K in human and mouse whole cell lysates.

Please note: MSD has transitioned this product to a status of “made-to-order” with a minimum order size of 25 plates. For an order of the 5-plate pack size, the minimum quantity is 5 packs (25 plates). The 1-plate and 20-plate pack sizes have been discontinued.

Specifications
Documentation
References

Application(s)		Phosphoproteins , Intracellular Signaling
Analyte(s)		p70S6K
Species		Human, Mouse, Rat
Instrument(s)		SECTOR Imager 2400 , MESO SECTOR S 600MM , SECTOR Imager 6000 , MESO QuickPlex SQ 120MM , MESO QuickPlex SQ 120 , MESO SECTOR S 600
Plate Type		96-well
Capture Antibody		Phospho-p70S6K: Rabbit Polyclonal Total p70S6K: Mouse Monoclonal
Detection Antibody		Phospho-p70S6K: Goat Polyclonal Total p70S6K: Goat Polyclonal
Usage Statement		For Research Use Only. Not for use in diagnostic procedures.
Kit Model		Whole Cell Lysate
Storage Statement(s)		Please refer to the product insert for the storage conditions of individual kit components.
Storage Condition		Multi-Component

Contact Information

Customer Service/Orders
1-240-314-2795

5:00 a.m. to 8:00 p.m.
US Eastern Time

Email

Scientific/Technical Support
1-240-314-2798

5:30 a.m. to 5:30 p.m.
US Eastern Time

Email

Instrument Support
1-301-947-2057

8:30 a.m. - 5:30 p.m.
US Eastern Time

Email

Company Headquarters
1-240-314-2600
1601 Research Blvd.
Rockville, Maryland 20850-3173
USA

Product Inserts		Phospho Thr 421 Ser 424 Total p70S6K WCL
Datasheets		DS Phospho Thr 421 Ser 424 Total p70S6K
SDS		Blocker A Phosphatase Inhibitor I Protease Inhibitor Solution Read Buffer T (4x), Read Buffer S (4x) and Read Buffer S (1x) Tris Lysis Buffer Tris Wash Buffer (10x)

Title	Journal	Year
S49076 is a novel kinase inhibitor of MET, AXL and FGFR with strong preclinical activity alone and in association with bevacizumab. Burbridge MF, Bossard CJ, Saunier C, Fejes I, Bruno A, Leonce S, Ferry G, Da Violante G, Bouzom F, Cattan V, Jacquet-Bescond A, Comoglio PM, Lockhart BP, Boutin JA, Cordi A, Ortuno JC, Pierre A, Hickman JA, Cruzalegui FH, Depil S.	Mol Cancer Ther.	2013
AT13148 is a novel, oral multi-AGC kinase inhibitor with potent pharmacodynamic and antitumor activity. Yap TA, Walton MI, Grimshaw KM, Te Poele RH, Eve PD, Valenti MR, de Haven BAK, Martins V, Zetterlund A, Heaton SP, Heinzmann K, Jones PS, Feltell RE, Reule M, Woodhead SJ, Davies TG, Lyons JF, Raynaud FI, Eccles SA, Workman P, Thompson NT, Garrett MD.	Clin Cancer Res.	2012
Mechanism of anti-glioma activity and in vivo efficacy of the cannabinoid ligand KM-233. Gurley SN, Abidi AH, Allison P, Guan P, Duntsch C, Robertson JH, Kosanke SD, Keir ST, Bigner DD, Elberger AJ, Moore BM 2nd.	J Neurooncol.	2012
The Association of PI3 Kinase Signaling and Chemoresistance in Advanced Ovarian Cancer. Carden CP, Stewart A, Thavasu P, Kipps E, Pope L, Crespo M, Miranda S, Attard G, Garrett MD, Clarke PA, Workman P, de Bono JS, Gore M, Kaye SB, Banerji U.	Mol Cancer Ther.	2012
Efficacy of Ganitumab (AMG 479), Alone and in Combination With Rapamycin, in Ewing's and Osteogenic Sarcoma Models. Beltran, P.J., Chung, Y.A., Moody, G., Mitchell, P., Cajulis, E., Vonderfecht, S., Kendall, R., Radinsky, R., Calzone, F.J.	Pharmacol Exp Ther.	2011
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Phospho (Thr421/Ser424)/Total p70S6K Whole Cell Lysate Kit 5

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