U-PLEX Biomarker Group 1 (NHP) 59-Plex

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The U-PLEX Biomarker Group 1 (NHP) 59-Plex is a large panel of biomarkers that has been tested for multiplex compatibility and is fulfilled as a kit. It contains an extensive combination of assays for NHP cytokines and chemokines that are involved in immune responses and regulation (Table 1). The assays can be used for quantitative measurements in serum, plasma, or cell culture supernatants, and offer detection limits (LLODs) in the sub- to low pg/mL range.

Table 1. List of analytes and typical detection limits

Analyte	LLOD - ULOD	units
CTACK	1.8 - 4,200	pg/mL
ENA-78	0.36 - 3,900	pg/mL
Eotaxin	0.30 - 4,800	pg/mL
Eotaxin-2	3.1 - 6,000	pg/mL
Eotaxin-3	7.3 - 21,400	pg/mL
FLT3L	0.49 - 6,000	pg/mL
Fractalkine	100 - 181,000	pg/mL
G-CSF	1.5 - 20,400	pg/mL
GM-CSF	0.12 - 9,400	pg/mL
GRO-α	0.25 - 2,500	pg/mL
I-309	6.8 - 3,000	pg/mL
IFN-α2a	1.7 - 40,800	pg/mL
IFN-γ	1.7 - 17,000	pg/mL
IL-1α	0.60 - 5,100	pg/mL
IL-1β	0.15 - 3,800	pg/mL
IL-1RA	1.7 - 5,000	pg/mL
IL-2	0.70 - 1,900	pg/mL
IL-4	0.063 - 2,100	pg/mL
IL-5	0.24 - 4,000	pg/mL
IL-6	0.33 - 2,000	pg/mL

Analyte	LLOD - ULOD	units
IL-7	1.5 - 7,000	pg/mL
IL-8	0.15 - 2,200	pg/mL
IL-9	0.14 - 1,500	pg/mL
IL-10	0.14 - 3,700	pg/mL
IL-12/IL-23p40	2.8 - 21,000	pg/mL
IL-12p70	0.54 - 5,300	pg/mL
IL-13	1.2 - 1,900	pg/mL
IL-15	0.82 - 3,000	pg/mL
IL-16	6.6 - 21,500	pg/mL
IL-17A	2.5 - 23,400	pg/mL
IL-17A/F	1.8 - 18,400	pg/mL
IL-17B	0.79 - 4,000	pg/mL
IL-17C	2.2 - 20,000	pg/mL
IL-17D	4.8 - 40,000	pg/mL
IL-17F	160 - 112,000	pg/mL
IL-18	2.5 - 42,000	pg/mL
IL-22	0.13 - 3,400	pg/mL
IL-23	1.4 - 21,600	pg/mL
IP-10	0.49 - 6,000	pg/mL
I-TAC	1.5 - 2,000	pg/mL

Analyte	LLOD - ULOD	units
MCP-1	0.74 - 6,600	pg/mL
MCP-2	0.11 - 2,000	pg/mL
MCP-4	7.5 - 3,800	pg/mL
M-CSF	0.29 - 2,000	pg/mL
MDC	8.4 - 20,100	pg/mL
MIF	4.3 - 27,000	pg/mL
MIP-1α	7.7 - 4,200	pg/mL
MIP-1β	1.5 - 1,600	pg/mL
MIP-3α	0.27 - 20,800	pg/mL
MIP-3β	0.67 - 2,000	pg/mL
MIP-5	0.34 - 30,000	pg/mL
SDF-1α	18 - 103,000	pg/mL
TARC	0.51 - 2,200	pg/mL
TNF-α	0.54 - 3,700	pg/mL
TNF-β	0.47 - 4,300	pg/mL
TPO	19 - 40,400	pg/mL
TRAIL	0.66 - 10,000	pg/mL
VEGF-A	2.0 - 4,900	pg/mL
YKL-40	0.39 - 5,000	pg/mL

Specifications
Documentation
References

Application(s)		Cytokines & Chemokines , Immunology/Inflammation
Analyte(s)		CTACK, ENA-78, Eotaxin, Eotaxin-2, Eotaxin-3, FLT3L, Fractalkine, G-CSF, GM-CSF, GRO-α, I-309, IFN-α2a, IFN-γ, IL-1α, IL-1β, IL-1RA, IL-2, IL-4, IL-5, IL-6, IL-7, IL-8, IL-9, IL-10, IL-12/IL-23p40, IL-12p70, IL-13, IL-15, IL-16, IL-17A, IL-17A/F, IL-17B, IL-17C, IL-17D, IL-17F, IL-18, IL-22, IL-23, IP-10, I-TAC, MCP-1, MCP-2, MCP-4, M-CSF, MDC, MIF, MIP-1α, MIP-1β, MIP-3α, MIP-3β, MIP-5, SDF-1α, TARC, TNF-α, TNF-β, TPO, TRAIL, VEGF-A, YKL-40
Species		Non-human primate
Instrument(s)		SECTOR Imager 2400 , MESO SECTOR S 600MM , SECTOR Imager 6000 , MESO QuickPlex SQ 120MM , MESO QuickPlex SQ 120 , MESO SECTOR S 600
U-PLEX Group Compatibility		Biomarker Group 1
Plate Type		96-well
Sample Type		Serum, Plasma, Cell Culture Supernatant
Usage Statement		For Research Use Only. Not for use in diagnostic procedures.
Storage Statement(s)		Please refer to the product insert for the storage conditions of individual kit components.
Storage Condition		Multi-Component
Schedule B Code		3822.19.0000

Contact Information

Customer Service/Orders
1-240-314-2795

5:00 a.m. to 8:00 p.m.
US Eastern Time

Email

Scientific/Technical Support
1-240-314-2798

5:30 a.m. to 5:30 p.m.
US Eastern Time

Email

Instrument Support
1-301-947-2057

8:30 a.m. - 5:30 p.m.
US Eastern Time

Email

Company Headquarters
1-240-314-2600
1601 Research Blvd.
Rockville, Maryland 20850-3173
USA

Product Inserts		U-PLEX Biomarker Group 1 (NHP) Multiplex Insert
Datasheets		DS 1C U-PLEX NHP GRO-α U-PLEX NHP CTACK U-PLEX NHP ENA-78 U-PLEX NHP Eotaxin U-PLEX NHP Eotaxin-2 U-PLEX NHP Eotaxin-3 U-PLEX NHP FLT3L View More
Product Highlights		U-PLEX Platform Highlights
SDS		Biotin-conjugated Antibodies Safety Data Sheet Diluent 2, Diluent 3, Diluent 5, Diluent 7 and Diluent 8 Diluent 41, Diluent 43 and Diluent 45 Diluent 50, Diluent 56, Diluent 61, Diluent 100, and Diluent 101 MSD Calibrators and Controls MSD GOLD Read Buffer B Read Buffer T (4x), Read Buffer S (4x) and Read Buffer S (1x) U-PLEX Linker Set

Title	Journal	Year
Twenty-eight day repeated exposure of human 3D bronchial epithelial model to heated tobacco aerosols indicates decreased toxicological responses compared to cigarette smoke Fiona Chapman, Sarah Jean Pour, Roman Wieczorek, Edgar Trelles Sticken, Jessica Budde, Karin Röwer, Sandra Otte, Elizabeth Mason, Lukasz Czekala, Thomas Nahde, Grant O’Connell, Liam Simms and Matthew Stevenson	Frontiers in Toxicology	2023
A phase 1 study of prophylactic anakinra to mitigate ICANS in patients with large B-cell lymphoma Paolo Strati, Andrew Jallouk, Qing Deng, Xubin Li, Lei Feng, Ryan Sun, Sherry Adkins, Swapna Johncy, Taylor Cain, Raphael E. Steiner, Sairah Ahmed, Dai Chihara, Luis E. Fayad, Swaminathan P. Iyer, Sandra Horowitz, Loretta J. Nastoupil, Ranjit Nair, Ahmed Hassan, Taher E. Daoud, Misha Hawkins, Maria A. Rodriguez, Elizabeth J. Shpall, Jeremy L. Ramdial, Partow Kebriaei, David S. Hong, Jason R. Westin, Sattva S. Neelapu, Michael R. Green	Blood Advances	2023
Viral Antigen and Inflammatory Biomarkers in Cerebrospinal Fluid in Patients With COVID-19 Infection and Neurologic Symptoms Compared With Control Participants Without Infection or Neurologic Symptoms Arvid Edén, Anna Grahn, Daniel Bremell, Anahit Aghvanyan, Pradeepthi Bathala, Dietmar Fuchs, Johanna Gostner, Lars Hagberg, Nelly Kanberg, Sunsanee Kanjananimmanont, Magnus Lindh, Salvia Misaghian, Staffan Nilsson, Michael Schöll, George Sigal, Erika Stentoft, Marie Studahl, Aylin Yilmaz, Mingyue Wang, Martin Stengelin, Henrik Zetterberg, Magnus Gisslén	JAMA Network Open	2022
Characterization and Biomarker Analyses of Post-COVID-19 Complications and Neurological Manifestations Bing Sun, Norina Tang, Michael J. Peluso, Nikita S. Iyer, Leonel Torres, Joanna L. Donatelli, Sadie E. Munter, Christopher C. Nixon, Rachel L. Rutishauser, Isabel Rodriguez-Barraquer, Bryan Greenhouse, John D. Kelly, Jeffrey N. Martin, Steven G. Deeks, Timothy J. Henrich, and Lynn Pulliam	Cells	2021
Galectin-9, a Player in Cytokine Release Syndrome and a Surrogate Diagnostic Biomarker in SARS-CoV-2 Infection Najmeh Bozorgmehr, Siavash Mashhouri, Eliana Perez Rosero, Lai Xu, Shima Shahbaz, Wendy Sligl, Mohammed Osman, Demetrios J. Kutsogiannis, Erika MacIntyre, Conar R. O’Neil, Shokrollah Elahi	mBio	2021
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