Human TH1/TH2 7-Plex Base Kit

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The Human TH1/TH2 7-Plex Base Kit provides basic components for the simultaneous quantitative determination of both natural and recombinant human IFN-γ, IL-2, IL-4, IL-5, IL-10, IL-12p70, and IL-13. Base kits generally include only MSD plates coated with the capture antibody, SULFO-TAG-labeled antibody, and MSD proprietary read buffer. (See product insert for a list of kit components). Base kits are most commonly used for high-throughput screening and assay development.

Specifications
Documentation
References

Application(s)		Cytokines & Chemokines , Immunology/Inflammation
Analyte(s)		IFN-γ, IL-2, IL-4, IL-5, IL-10, IL-12p70, IL-13
Species		Human
Instrument(s)		SECTOR Imager 2400 , SECTOR Imager 6000 , MESO QuickPlex SQ 120 , MESO QuickPlex SQ 120MM , MESO SECTOR S 600 , MESO SECTOR S 600MM
Plate Type		96-well
Capture Antibody		IFN-γ: Mouse Monoclonal IL-2: Mouse Monoclonal IL-4: Mouse Monoclonal IL-5: Mouse Monoclonal IL-10: Rat Monoclonal IL-12p70: Mouse Monoclonal IL-13: Rat Monoclonal
Detection Antibody		IFN-γ: Mouse Monoclonal IL-2: Mouse Monoclonal IL-4: Rat Monoclonal IL-5: Mouse Monoclonal IL-10: Rat Monoclonal IL-12p70: Mouse Monoclonal IL-13: Goat Polyclonal
LLOD (Sensitivity)		IFN-γ: 0.55 pg/mL IL-2: 0.45 pg/mL IL-4: 0.30 pg/mL IL-5: 0.08 pg/mL IL-10: 0.51 pg/mL IL-12p70: 2.02 pg/mL IL-13: 1.3 pg/mL
Dynamic Range		IFN-γ: 0.55-10000 pg/mL IL-2: 0.45-10000 pg/mL IL-4: 0.30-10000 pg/mL IL-5: 0.08-10000 pg/mL IL-10: 0.51-10000 pg/mL IL-12p70: 2.02-10000 pg/mL IL-13: 1.3-10000 pg/mL
Sample Type		Serum, Plasma
Recombinant standards		IFN-γ, IL-2, IL-4,IL-13: Recombinant protein expressed in E. coli IL-5, IL-10, IL-12p70: Recombinant protein expressed in insect cells
Usage Statement		For Research Use Only. Not for use in diagnostic procedures.
Storage Statement(s)		Please refer to the product insert for the storage conditions of individual kit components.
Storage Condition		2-8 °C

Title	Journal	Year
Viral Antigen and Inflammatory Biomarkers in Cerebrospinal Fluid in Patients With COVID-19 Infection and Neurologic Symptoms Compared With Control Participants Without Infection or Neurologic Symptoms Arvid Edén, Anna Grahn, Daniel Bremell, Anahit Aghvanyan, Pradeepthi Bathala, Dietmar Fuchs, Johanna Gostner, Lars Hagberg, Nelly Kanberg, Sunsanee Kanjananimmanont, Magnus Lindh, Salvia Misaghian, Staffan Nilsson, Michael Schöll, George Sigal, Erika Stentoft, Marie Studahl, Aylin Yilmaz, Mingyue Wang, Martin Stengelin, Henrik Zetterberg, Magnus Gisslén	JAMA Network Open	2022
Characterization and Biomarker Analyses of Post-COVID-19 Complications and Neurological Manifestations Bing Sun, Norina Tang, Michael J. Peluso, Nikita S. Iyer, Leonel Torres, Joanna L. Donatelli, Sadie E. Munter, Christopher C. Nixon, Rachel L. Rutishauser, Isabel Rodriguez-Barraquer, Bryan Greenhouse, John D. Kelly, Jeffrey N. Martin, Steven G. Deeks, Timothy J. Henrich, and Lynn Pulliam	Cells	2021
Galectin-9, a Player in Cytokine Release Syndrome and a Surrogate Diagnostic Biomarker in SARS-CoV-2 Infection Najmeh Bozorgmehr, Siavash Mashhouri, Eliana Perez Rosero, Lai Xu, Shima Shahbaz, Wendy Sligl, Mohammed Osman, Demetrios J. Kutsogiannis, Erika MacIntyre, Conar R. O’Neil, Shokrollah Elahi	mBio	2021
Anti-SARS-CoV-2 IgG from severely ill COVID-19 patients promotes macrophage hyper-inflammatory responses Willianne Hoepel, Hung-Jen Chen, Sona Allahverdiyeva, Xue Manz, Jurjan Aman, Amsterdam UMC COVID-19 Biobank, Peter Bonta, Philip Brouwer, Steven de Taeye, Tom Caniels, Karlijn van der Straten, Korneliusz Golebski, Guillermo Griffith, René Jonkers, Mads Larsen, Federica Linty, Annette Neele, Jan Nouta, Frank van Baarle, Cornelis van Drunen, Alexander Vlaar, Godelieve de Bree, Rogier Sanders, Lisa Willemsen, Manfred Wuhrer, Harm Jan Bogaard, Marit van Gils, Gestur Vidarsson, Menno de Winther, Jeroen den Dunnen	TBD	2020
Multisystem inflammatory syndrome in children and COVID-19 are distinct presentations of SARS–CoV-2 Caroline Diorio, Sarah E. Henrickson, Laura A. Vella, Kevin O. McNerney, Julie Chase, Chakkapong Burudpakdee, Jessica H. Lee, Cristina Jasen, Fran Balamuth, David M. Barrett, Brenda L. Banwell, Kathrin M. Bernt, Allison M. Blatz, Kathleen Chiotos, Brian T. Fisher, Julie C. Fitzgerald, Jeffrey S. Gerber, Kandace Gollomp, Christopher Gray, Stephan A. Grupp, Rebecca M. Harris, Todd J. Kilbaugh, Audrey R. Odom John, Michele Lambert, Emily J. Liebling, Michele E. Paessler, Whitney Petrosa, Charles Phillips, Anne F. Reilly, Neil D. Romberg, Alix Seif, Deborah A. Sesok-Pizzini, Kathleen E. Sullivan, Julie Vardaro, Edward M. Behrens, David T. Teachey, Hamid Bassiri	The Journal of Clinical Investigation	2020
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Product Inserts		Human 96 well Base
SDS		Diluent 50, Diluent 56, Diluent 61, Diluent 100, and Diluent 101 Read Buffer T (4x), Read Buffer S (4x) and Read Buffer S (1x)

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