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The Human Bone Marker Panel I Base Kit provides basic components for the quantitative determination of both natural and recombinant human osteoprotegerin (OPGN), sclerostin (SOST), and alkaline phosphatase (ALP) in serum and plasma. Base kits generally include only MSD plates coated with the capture antibody, SULFO-TAG-labeled antibody, and MSD proprietary read buffer. (See product insert for a list of kit components). Base kits are most commonly used for high-throughput screening and assay development.
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Specifications
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Documentation
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References
Application(s)
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Bone Disorders
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Analyte(s)
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ALP, Osteoprotegerin, Sclerostin
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Species
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Human
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Instrument(s)
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SECTOR Imager 2400
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SECTOR Imager 6000
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MESO QuickPlex SQ 120
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MESO QuickPlex SQ 120MM
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MESO SECTOR S 600
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MESO SECTOR S 600MM
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Plate Type
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96-well
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Capture Antibody
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Osteoprotegerin: Goat Polyclonal Sclerostin: Goat Polyclonal Alkaline Phosphatase: Mouse Monoclonal
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Detection Antibody
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Osteoprotegerin: Mouse Monoclonal Sclerostin: Goat Polyclonal Alkaline Phosphatase: Mouse Monoclonal
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LLOD (Sensitivity)
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Osteoprotegerin: 0.004 ng/mL Sclerostin: 0.004 ng/mL Alkaline Phosphatase: 1.9 ng/mL
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Dynamic Range
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Osteoprotegerin: 0.004 - 200 ng/mL Sclerostin: 0.004 - 100 ng/mL Alkaline Phosphatase: 1.9 - 4000 ng/mL
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Sample Type
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Serum, Plasma
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Recombinant standards
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Osteoprotegerin: Recombinant human protein expressed in a mouse myeloma cell line Sclerostin: Recombinant human protein expressed in a mouse myeloma cell line Alkaline Phosphatase: Recombinant human protein expressed in a mouse myeloma cell line
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Usage Statement
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For Research Use Only. Not for use in diagnostic procedures.
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Storage Statement(s)
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Please refer to the product insert for the storage conditions of individual kit components.
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Storage Condition
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2-8 °C
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Product Inserts
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Datasheets
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SDS
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Title
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Journal
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Year
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Development of a multi-biomarker disease activity test for rheumatoid arthritis.
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First missense mutation in the SOST gene causing sclerosteosis by loss of sclerostin function.
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Serum correlates of the placebo effect in irritable bowel syndrome.
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Sex and ethnic differences in 47 candidate proteomic markers of cardiovascular disease: the mayo clinic proteomic markers of arteriosclerosis study.
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