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The Cardiac Injury Panel 2 (rat) Kit provides assay-specific components for the quantitative determination of both natural and recombinant rat cardiac troponin I (cTnI), cardiac troponin T (cTnT), fatty acid binding protein 3 (FABP3) in serum and plasma.
Troponin is a heterodimer that regulates muscle contraction in skeletal and cardiac muscle. Troponin acts with intracellular calcium to control the interaction of actin and myosin filaments in striated muscle fibers. When muscle tissue is damaged, the troponin-tropomyosin complex breaks down and troponin I and troponin T are released into the blood. cTnI and cTnT can be readily distinguished from their skeletal muscle making them excellent biomarkers for myocardial injury and cardiotoxicity. FABP3 is a monomeric protein that modulates the uptake of fatty acids in cells. Heart-type fatty acid binding protein is released into circulation after myocardial ischemia and necrosis. FABP3 is mostly present in heart and skeletal muscle but can also be found in brain, liver, and small intestine.
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Specifications
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Documentation
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References
Application(s)
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Cardiac Biomarkers
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Toxicology
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Cardiac Injury
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Cardiovascular
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Analyte(s)
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FABP3/H-FABP, Troponin I (cardiac), Troponin T (cardiac)
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Species
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Rat
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Instrument(s)
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SECTOR Imager 2400
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MESO SECTOR S 600MM
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SECTOR Imager 6000
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MESO QuickPlex SQ 120MM
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MESO QuickPlex SQ 120
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MESO SECTOR S 600
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Plate Type
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96-well
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Capture Antibody
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cTnI: Mouse Monoclonal cTnT: Mouse Monoclonal FABP3: Chicken Polyclonal
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Detection Antibody
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cTnI: Mouse Monoclonal cTnT: Mouse Monoclonal FABP3: Mouse Monoclonal
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LLOD (Sensitivity)
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cTnI: 0.011 ng/mL cTnT: 0.117 ng/mL FABP3: 0.026 ng/mL
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LLOQ (Sensitivity)
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cTnI: 0.098 ng/mL cTnT: 0.49 ng/mL FABP3: 0.39 ng/mL
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ULOQ (Sensitivity)
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cTnI: 20 ng/mLcTnT: 35 ng/mLFABP3: 25 ng/mL
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Dynamic Range
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cTnI: 0.011 - 25 ng/mL cTnT: 0.117 - 50 ng/mL FABP3: 0.026 - 100 ng/mL
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Sample Type
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Serum, Plasma
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Recombinant standards
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cTnI, rat cTnT and rat FABP3 proteins purified from rat heart tissue
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Usage Statement
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For Research Use Only. Not for use in diagnostic procedures.
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Storage Statement(s)
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Please refer to the product insert for the storage conditions of individual kit components.
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Storage Condition
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Multi-Component
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Schedule B Code
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3822.19.0000
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Product Inserts
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Certificate of analysis
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SDS
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Scientific Posters
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Title
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Journal
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Year
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A sensitive and specific quantitation method for determination of serum cardiac Myosin binding protein-C by electrochemiluminescence immunoassay.
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Cellular impedance assays for predictive preclinical drug screening of kinase inhibitor cardiovascular toxicity.
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Doxycycline reduces cardiac Matrix Metalloproteinase-2 activity but does not ameliorate myocardial dysfunction during reperfusion in coronary artery bypass patients undergoing cardiopulmonary bypass.
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Dystrophin-deficient cardiomyocytes derived from human urine: New biologic reagents for drug discovery.
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Mild oxidative damage in the diabetic rat heart is attenuated by glyoxalase-1 overexpression.
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