| References | Journal | Year | |
Robust Central Reduction of Amyloid-β in Humans with an Orally Available, Non-Peptidic β-Secretase Inhibitor.
May, P.C., Dean, R.A., Lowe, S.L., Martenyi, F., Sheehan, S.M., Boggs, L.N., Monk, S.A., Mathes, B.M., Mergott, D.J., Watson, B.M., Stout, S.L., Timm, D.E., Labell, S.E., Gonzales, C.R., Nakano, M., Jhee, S.S., Yen, M., Ereshefsky, L., Lindstrom, T.D., Calligaro, D.O., Cocke, P.J., Hall, G.D., Friedrich, S., Citron, M., Audia, J.E. | J Neurosci. | 2011 | View |
Safety, Efficacy, and Biomarker Exploration in a Phase II Study of Bevacizumab, Oxaliplatin, and Gemcitabine in Recurrent Müllerian Carcinoma.
Horowitz, N.S., Penson, R.T., Duda, D.G., di Tomaso, E., Boucher, Y., Ancukiewicz, M., Cohen, K.S., Berlin, S., Krasner, C.N., Moses, M.A., Jain, R.K. | Clin Ovarian Cancer Other Gynecol Malig. | 2011 | View |
Safety evaluation of chronic intrathecal administration of idursulfase-IT in cynomolgus monkeys.
Felice, B.R., Wright, T.L., Boyd, R.B., Butt, M.T., Pfeifer, R.W., Pan, J., Ruiz, J.A., Heartlein, M.W., Calias, P. | Toxicol Pathol. | 2011 | View |
Serum protein profiling of systemic lupus erythematosus and systemic sclerosis using recombinant antibody microarrays.
Carlsson, A., Wuttge, D.M., Ingvarsson, J., Bengtsson, A.A., Sturfelt, G., Borrebaeck, C.A., Wingren, C. | Mol Cell Proteomics. | 2011 | View |
Short-term walnut consumption increases circulating total adiponectin and apolipoprotein A concentrations, but does not affect markers of inflammation or vascular injury in obese humans with the metabolic syndrome: data from a double-blinded, randomized, placebo-controlled study.
Aronis, K.N., Vamvini, M.T., Chamberland, J.P., Sweeney, L.L., Brennan, A.M., Magkos, F., Mantzoros, C.S. | Metabolism. | 2011 | View |
Single and combination herpes simplex virus type 2 glycoprotein vaccines adjuvanted with CpG oligodeoxynucleotides or monophosphoryl lipid A exhibit differential immunity that is not correlated to protection in animal models.
Khodai, T., Chappell, D., Christy, C., Cockle, P., Eyles, J., Hammond, D., Gore, K., McCluskie, M.J., Evans, D.M., Lang, S., Loudon, P.T., Townend, T., Wright, P., West, K., Bright, H. | Clin Vaccine Immunol. | 2011 | View |
Single nucleotide polymorphisms that increase expression of the guanosine triphosphatase RAC1 are associated with ulcerative colitis.
Muise, A.M., Walters, T., Xu, W., Shen-Tu, G., Guo, C.H., Fattouh, R., Lam, G.Y., Wolters, V.M., Bennitz, J., van Limbergen, J., Renbaum, P., Kasirer, Y., Ngan, B.Y., Turner, D., Denson, L.A., Sherman, P.M., Duerr, R.H., Cho, J., Lees, C.W., Satsangi, J., Wilson, D.C., Paterson, A.D., Griffiths, A.M., Glogauer, M., Silverberg, M.S., Brumell, J.H. | Gastroenterology. | 2011 | View |
Single-dose, placebo-controlled, randomized study of AMG 785, a sclerostin monoclonal antibody.
Padhi, D., Jang, G., Stouch, B., Fang, L., Posvar, E | JBMR | 2011 | View |
SirT1 Regulates Adipose Tissue Inflammation.
Gillum, M.P., Kotas, M.E., Erion, D.M., Kursawe, R., Chatterjee, P., Nead, K.T., Muise, E.S., Hsiao, J.J., Frederick, D.W., Yonemitsu, S., Banks, A.S., Qiang, L., Bhanot, S., Olefsky, J.M., Sears, D.D., Caprio, S., Shulman, G.I. | Diabetes. | 2011 | View |
Small molecule inhibitors of FABP4/5 ameliorate dyslipidemia but not insulin resistance in mice with diet-induced obesity.
Lan, H., Cheng, C.C., Kowalski, T.J., Pang, L., Shan, L., Chuang, C.C., Jackson, J., Rojas-Triana, A., Bober, L., Liu, L., Voigt, J., Orth, P., Yang, X., Shipps, G.W. Jr, Hedrick, J.A. | J Lipid Res. | 2011 | View |
Social disruption stress increases IL-6 levels and accelerates atherosclerosis in ApoE(-/-) mice.
Bernberg E, Ulleryd MA, Johansson ME, Bergström GM. | Atherosclerosis | 2011 | View |
Soluble Beta-Amyloid Precursor Protein Is Related to Disease Progression in Amyotrophic Lateral Sclerosis.
Steinacker, P., Fang, L., Kuhle, J., Petzold, A., Tumani, H., Ludolph, A.C., Otto, M., Brettschneider, J. | PLoS ONE | 2011 | View |
Sphingolipid storage affects autophagic metabolism of the amyloid precursor protein and promotes Abeta generation.
Tamboli, I.Y., Hampel, H., Tien, N.T., Tolksdorf, K., Breiden, B., Mathews, P.M., Saftig, P., Sandhoff, K., Walter, J. | J Neurosci. | 2011 | View |
Stable IgG-like bispecific antibodies directed toward the type I insulin-like growth factor receptor demonstrate enhanced ligand blockade and anti-tumor activity.
Dong, J., Sereno, A., Snyder, W.B., Miller, B.R., Tamraz, S., Doern, A., Favis, M., Wu, X., Tran, H., Langley, E., Joseph, I., Boccia, A., Kelly, R., Wortham, K., Wang, Q., Berquist, L., Huang, F., Gao, S.X., Zhang, Y., Lugovskoy, A., Martin, S., Gouvis, H., Berkowitz, S., Chiang, G., Reff, M., Glaser, S.M., Hariharan, K., Demarest, S.J. | J Biol Chem. | 2011 | View |
Surface molecules on stimulated plasmacytoid dendritic cells are sufficient to cross-activate resting myeloid dendritic cells.
Cantisani, R., Sammicheli, C., Tavarini, S., D'Oro, U., Wack, A., Piccioli, D. | Hum Immunol. | 2011 | View |
Synthetic double-stranded RNA induces innate immune responses similar to a live viral vaccine in humans.
Caskey M, Lefebvre F, Filali-Mouhim A, Cameron MJ, Goulet JP, Haddad EK, Breton G, Trumpfheller C, Pollak S, Shimeliovich I, Duque-Alarcon A, Pan L, Nelkenbaum A, Salazar AM, Schlesinger SJ, Steinman RM, Sékaly RP. | J Exp Med. | 2011 | View |
Systemic responses of preterm newborns with presumed or documented bacteremia.
Leviton, A., O'Shea, M.T., Bednarek, F.J., Allred, E.N., Fichorova, R.N., Dammann, O.; for the ELGAN Study Investigators. | Acta Paediatr. | 2011 | View |
Tenascin-C induces inflammatory mediators and matrix degradation in osteoarthritic cartilage.
Patel, L., Sun, W., Glasson, S.S., Morris, E.A., Flannery, C.R., Chockalingam, P.S. | BMC Musculoskelet Disord. | 2011 | View |
The Alzheimer's Association external quality control program for cerebrospinal fluid biomarkers.
Mattsson, N., Andreasson, U., Persson, S., Arai, H., Batish, S.D., Bernardini, S., et al. | Alzheimers Dement. | 2011 | View |
The Antagonists But Not Partial Agonists of Glucocorticoid Receptor Ligands Show Substantial Side Effect Dissociation.
Hu, X., Du, S., Tunca, C., Braden, T., Long, K.R., Lee, J., Webb, E.G., Dietz, J.D., Hummert, S., Rouw, S., Hegde, S.G., Webber, R.K., Obukowicz, M.G. | Endocrinology | 2011 | View |
The biochemical response to biomechanical tissue loading on the low back during physical work exposure.
Yang, G., Marras, W.S., Best, T.M. | Clin Biomech (Bristol, Avon). | 2011 | View |
The effect of antioxidant supplementation on insulin-sensitivity in response to endurance exercise training.
Yfanti, C., Nielsen, A.R., Akerstrom, T.C., Nielsen, S., Rose, A.J., Richter, E.A., Lykkesfeldt, J., Fischer, C.P., Pedersen, B.K. | Am J Physiol Endocrinol Metab. | 2011 | View |
The FGFR D3 Domain Determines Receptor Selectivity For Fibroblast Growth Factor 21.
Gupte, J., Yang, L., Wu, X., Weiszmann, J., Hecht, R., Lemon, B., Lindberg, R., Wang, Z., Li, Y. | J Mol Biol. | 2011 | View |
The hydroxylase inhibitor dimethyloxallyl glycine attenuates endotoxic shock via alternative activation of macrophages and IL-10 production by b1 cells.
Hams, E., Saunders, S.P., Cummins, E.P., O'Connor, A., Tambuwala, M.T., Gallagher, W.M., Byrne, A., Campos-Torres, A., Moynagh, P.M., Jobin, C., Taylor, C.T., Fallon, P.G. | Shock | 2011 | View |
The Innate Immune Response, Clinical Outcomes, and Ex Vivo HCV Antiviral Efficacy of a TLR7 Agonist (PF-4878691).
Fidock, M.D., Souberbielle, B.E., Laxton, C., Rawal, J., Delpuech-Adams, O., Corey, T.P., Colman, P., Kumar, V., Cheng, J.B., Wright, K., Srinivasan, S., Rana, K., Craig, C., Horscroft, N., Perros, M., Westby, M., Webster, R., van der Ryst, E. | Clin Pharmacol Ther. | 2011 | View |
The neuropeptide calcitonin gene-related peptide affects allergic airway inflammation by modulating dendritic cell function.
Rochlitzer, S., Veres, T.Z,, Kühne, K., Prenzler, F., Pilzner, C., Knothe, S., Winkler, C., Lauenstein, H.D., Willart, M., Hammad, H., Müller, M., Krug, N., Lambrecht, B.N., Braun, A. | Clin Exp Allergy. | 2011 | View |
The Nitric Oxide Prodrug JS-K Is Effective against Non-Small-Cell Lung Cancer Cells In Vitro and In Vivo: Involvement of Reactive Oxygen Species.
Maciag, A.E., Chakrapani, H., Saavedra, J.E., Morris, N.L., Holland, R.J., Kosak, K.M., Shami, P.J., Anderson, L.M., Keefer, L.K. | J Pharmacol Exp Ther. | 2011 | View |
The NKT cell ligand agalactosylceramide suppresses allergic airway inflammation by induction of a Th1 response.
Knothe, S., Mutschler, V., Rochlitzera, S., Winkler, C., Ebensen, T., Guzman, C.A., Hohlfeld, J., Braun, A., Muller, M. | Vaccine. | 2011 | View |
The Relationship between Early Concentrations of 25 Blood Proteins and Cerebral White Matter Injury in Preterm Newborns: The ELGAN Study.
Leviton, A., Kuban, K., O'Shea, T.M., Paneth, N., Fichorova, R., Allred, E.N., Dammann, O. | J Pediatr. | 2011 | View |
The Second-Generation Active A{beta} Immunotherapy CAD106 Reduces Amyloid Accumulation in APP Transgenic Mice While Minimizing Potential Side Effects.
Wiessner, C., Wiederhold, K.H., Tissot, A.C., Frey, P., Danner, S., Jacobson, L.H., Jennings, G.T., Lüönd, R., Ortmann, R., Reichwald, J., Zurini, M., Mir, A., Bachmann, M.F., Staufenbiel, M. | J Neurosci. | 2011 | View |
The Swedish APP mutation alters the effect of genetically reduced BACE1 expression on the APP processing.
Rabe, S., Reichwald, J., Ammaturo, D., de Strooper, B., Saftig, P., Neumann, U., Staufenbiel, M. | J Neurochem. | 2011 | View |
Tobacco smoke exposure and altered nasal responses to live attenuated influenza virus.
Noah, T.L., Zhou, H., Monaco, J., Horvath, K., Herbst, M., Jaspers, I. | Environ Health Perspect. | 2011 | View |
Tumour tissue microenvironment can inhibit dendritic cell maturation in colorectal cancer.
Michielsen, A.J., Hogan, A.E., Marry, J., Tosetto, M., Cox, F., Hyland, J.M., Sheahan, K.D., O'Donoghue, D.P., Mulcahy, H.E., Ryan, E.J., O'Sullivan, J.N. | PLoS One. | 2011 | View |
Urine Biomarkers Predict Acute Kidney Injury and Mortality in Very Low Birth Weight Infants.
Askenazi, D.J., Montesanti, A., Hunley, H., Koralkar, R., Pawar, P., Shuaib, F., Liwo, A., Devarajan, P., Ambalavanan, N. | J Pediatr. | 2011 | View |
Validation of immunoassay for protein biomarkers: bioanalytical study plan implementation to support pre-clinical and clinical studies.
Valentin, M.A., Ma, S., Zhao, A., Legay, F., Avrameas, A. | J Pharm Biomed Anal. | 2011 | View |
Variance in the Acute Inflammatory Response to Prolonged Cycling Is Linked to Exercise Intensity.
Nieman, D.C., Konrad, M., Henson, D.A., Kennerly, K., Shanely, R.A., Wallner-Liebmann, S.J. | J Interferon Cytokine Res. | 2011 | View |
Whole-Molecule Antibody Engineering: Generation of a High-Affinity Anti-IL-6 Antibody with Extended Pharmacokinetics.
Finch, D.K., Sleeman, M.A., Moisan, J., Ferraro, F., Botterell, S., Campbell, J., Cochrane, D., Cruwys, S., England, E., Lane, S., Rendall, E., Sinha, M., Walker, C., Rees, G., Bowen, M.A., Schneider, A., Liang, M., Faggioni, R., Fung, M., Mallinder, P.R., Wilkinson, T., Kolbeck, R., Vaughan, T., Lowe, D.C. | J Mol Biol | 2011 | View |
Zinc Finger Protein Tristetraprolin Interacts with CCL3 mRNA and Regulates Tissue Inflammation.
Kang, J.G., Amar, M.J., Remaley, A.T., Kwon, J., Blackshear, P.J., Wang, P.Y., Hwang, P.M. | J Immunol Methods | 2011 | View |
A Dual-Monoclonal Sandwich ELISA Specific for Hepcidin-25
Butterfield AM, Luan P, Witcher DR, Manetta J, Murphy AT, Wroblewski VJ, Konrad RJ. | Clin Chem. | 2010 | View |
Two additive mechanisms impair the differentiation of 'substrate-selective' p38 inhibitors from classical p38 inhibitors in vitro.
Hendriks, B.S., Seidl, K.M., Chabot, J.R. | BMC Systems Biology. | 2010 | View |
A First-in-Human Study of Conatumumab in Adult Patients With Advanced Solid Tumors.
Herbst, R.S., Kurzrock, R., Hong, D.S., Valdivieso, M., Hsu, C.P., Goyal, L., Juan, G., Hwang, Y., Wong, S., Hill, J.S., Friberg, G., Lorusso, P. | Clinical Cancer Research | 2010 | View |
A highly sensitive electrochemiluminescence immunoassay for the neurofilament heavy chain protein.
Kuhle, J., Regeniter, A., Leppert, D., Mehling, M., Kappos, L., Lindberg, R.L., Petzold, A. | J Neuroimmunol. | 2010 | View |
A Long-Acting Tumor Necrosis Factor a-Binding Protein Demonstrates Activity in Both In Vitro and In Vivo Models of Endometriosis.
Altan, Z.M., Denis, D., Kagan, D., Grund, E.M., Palmer, S.S., Nataraja, S.G. | J Pharmacol. | 2010 | View |
A new method to isolate microglia from adult mice and culture them for an extended period of time.
Moussaud, S., Draheim, H.J. | J Neurosci Methods. | 2010 | View |
A novel Aß isoform pattern in CSF reflects g-secretase inhibition in Alzheimer disease.
Portelius, E., Dean, R.A., Gustavsson, M.K., Andreasson, U., Zetterberg, H., Siemers, E., Blennow, K. | Alzheimers Res Ther. | 2010 | View |
A novel gamma-fitting statistical method for anti-drug antibody assays to establish assay cut points for data with non-normal distribution.
Schlain, B., Amaravadi, L., Donley, J., Wickramasekera, A., Bennett, D., Subramanyam, M. | Journal of Immunological Methods | 2010 | View |
A novel small-molecule inhibitor of protein kinase D blocks pancreatic cancer growth in vitro and in vivo.
Harikumar, K.B., Kunnumakkara, A.B., Ochi, N., Tong, Z., Deorukhkar, A., Sung, B., Kelland, L., Jamieson, S., Sutherland, R., Raynham, T., Charles, M., Bagherazadeh, A., Foxton, C., Boakes, A., Farooq, M., Maru, D., Diagaradjane, P., Matsuo, Y., Sinnett-Smith, J., Gelovani, J., Krishnan, S., Aggarwal, B.B., Rozengurt, E., Ireson, C.R., Guha, S. | Mol Cancer Ther. | 2010 | View |
A phase Ib study of AMG 102 in combination with bevacizumab or motesanib in patients with advanced solid tumors.
Rosen, P.J., Sweeney, .CJ., Park, .DJ., Beaupre, D.M., Deng, H., Leitch, I.M., Shubhakar, P., Zhu, M., Oliner, K.S., Anderson, A., Yee, L.K. | Clin Cancer Res. | 2010 | View |
A plate-based assay to measure cellular ERK substrate phosphorylation: utility for drug discovery of the MAPK-signaling cascade.
Ramaswamy S, Yen I, Sideris S, Malek S, Heise CE. | Assay Drug Dev Technol | 2010 | View |
A Proteomic Approach for the Diagnosis of Bacterial Meningitis.
Jesse, S., Steinacker, P., Lehnert, S., Sdzuj, M., Cepek, L., Tumani, H., Jahn, O., Schmidt, H., Otto, M. | PLoS ONE | 2010 | View |