V-PLEX Plus Human IL-5 Kit


Human interleukin-5 (IL-5), also known as B-cell growth factor II (BCGF-II) and T-cell replacing factor (TRF), is a glycosylated 15.2 kDa homodimer protein with two internal disulfide bonds. It is mainly produced by eosinophils and Th2 cells. Its main function is to induce terminal differentiation of late-developing B-cells to immunoglobulin secreting cells. The IL-5 receptor consists of an α subunit and a βc subunit that is shared with the GM-CSF receptor. IL-5 initially binds to the α subunit with low affinity and then associates with the pre-formed βc subunit homodimer yielding a high-affinity interaction. IL-5 is associated with eosinophilia, atopic dermatitis, and pulmonary fibrosis along with other disorders.The Human IL-5 Kit provides assay-specific components for the quantitative determination of endogenous IL-5 in human urine, serum, plasma, and cell culture supernatants.

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