MSD offers a range of individual assays utilizing U-PLEX Antibody Sets that provide a rapid and convenient method for measuring biomarkers in complex matrices. The individual assays are offered on MSD GOLD Small Spot Streptavidin Plates and use the same antibody sets and diluents as the U-PLEX multiplex assays. This allows for efficient transfer between the individual assay and a higher throughput multiplex configuration. Typical of assays developed on the MSD platform, the individual assays have high sensitivity, excellent precision, provide up to five-logs of linear dynamic range, and require minimal sample volume. MIP-1β (CCL4), also known as lymphocyte activation gene 1 protein (LAG-1), G-26 T-lymphocyte-secreted protein, HC21, PAT 744, protein H400, SIS-gamma, small-inducible cytokine A4, and T-cell activation protein 2 (ACT-2), is a 10.2 kDa protein that binds to CCR5. CCR5 is shared between MIP-1β, MIP-1α, RANTES, and CCL3L1. MIP-1β is one of the major HIV suppressive factors produced by CD8+ T cells. It down-modulates the expression of CCR5 and thus inhibits the CCR5-mediated entry of HIV-1 into T-cells. MIP-1β occurs as a homodimer and as a heterodimer with MIP-1α. In addition to its involvement in HIV infection, MIP-1β plays a role in large granular lymphocyte leukemia and organ transplant rejection. The U-PLEX NHP MIP-1β Assay provides the components for the quantitative determination of both natural and recombinant MIP-1β in Cynomolgus monkey and Rhesus monkey serum, plasma, and cell culture supernatants.

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