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The IRS family of proteins are highly studied due to their roles in the very early phases of cancer as well as metastatic progression, and these proteins are seen to have potential both as therapeutic targets of drug development and diagnostic predictors of therapeutic effectiveness, due to their role in drug resistance. This kit provides assay-specific components for the quantitative determination of phospho-IRS-1 (Ser312) in human whole cell lysates.
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Specifications
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Documentation
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References
Application(s)
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Phosphoproteins
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Intracellular Signaling
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Analyte(s)
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IRS-1
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Species
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Human
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Instrument(s)
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SECTOR Imager 2400
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MESO SECTOR S 600MM
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SECTOR Imager 6000
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MESO QuickPlex SQ 120MM
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MESO QuickPlex SQ 120
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MESO SECTOR S 600
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Plate Type
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96-well
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Capture Antibody
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Mouse Monoclonal
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Detection Antibody
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Mouse Monoclonal
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Usage Statement
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For Research Use Only. Not for use in diagnostic procedures.
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Kit Model
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Whole Cell Lysate
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Storage Statement(s)
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Please refer to the product insert for the storage conditions of individual kit components.
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Storage Condition
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2-8 °C
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Schedule B Code
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3002.15.0100
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Product Inserts
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Datasheets
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SDS
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Title
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Journal
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Year
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Dependence of Wilms tumor cells on signaling through insulin-like growth factor 1 in an orthotopic xenograft model targetable by specific receptor inhibition.
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Neutrophils mediate insulin resistance in mice fed a high-fat diet through secreted elastase.
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Dual IGF-I/II-Neutralizing Antibody MEDI-573 Potently Inhibits IGF Signaling and Tumor Growth.
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Efficacy of Ganitumab (AMG 479), Alone and in Combination With Rapamycin, in Ewing's and Osteogenic Sarcoma Models.
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Chronic treatment with epoxyeicosatrienoic acids modulates insulin signaling and prevents insulin resistance in hepatocytes.
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