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The Human Bone Marker Panel I Kit provides assay-specific components for the quantitative determination of both natural and recombinant human osteoprotegerin (OPGN), sclerostin (SOST), and alkaline phosphatase (ALP) in serum and plasma.
Please note: MSD has transitioned this product to a status of “made-to-order” with a minimum order size of 25 plates. For an order of the 5-plate pack size, the minimum quantity is 5 packs (25 plates). The 1-plate and 20-plate pack sizes have been discontinued.
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Specifications
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Documentation
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References
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Application(s)
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Bone Disorders
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Analyte(s)
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ALP, Osteoprotegerin, Sclerostin
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Species
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Human
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Instrument(s)
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SECTOR Imager 2400
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MESO SECTOR S 600MM
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SECTOR Imager 6000
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MESO QuickPlex SQ 120MM
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MESO QuickPlex SQ 120
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MESO SECTOR S 600
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Plate Type
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96-well
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Capture Antibody
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Osteoprotegerin: Goat Polyclonal
Sclerostin: Goat Polyclonal
Alkaline Phosphatase: Mouse Monoclonal
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Detection Antibody
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Osteoprotegerin: Mouse Monoclonal
Sclerostin: Goat Polyclonal
Alkaline Phosphatase: Mouse Monoclonal
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LLOD (Sensitivity)
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Osteoprotegerin: 0.004 ng/mL
Sclerostin: 0.004 ng/mL
Alkaline Phosphatase: 1.9 ng/mL
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Dynamic Range
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Osteoprotegerin: 0.004 - 200 ng/mL
Sclerostin: 0.004 - 100 ng/mL
Alkaline Phosphatase: 1.9 - 4000 ng/mL
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Sample Type
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Serum, Plasma
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Recombinant standards
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Osteoprotegerin: Recombinant human protein expressed in a mouse myeloma cell line
Sclerostin: Recombinant human protein expressed in a mouse myeloma cell line
Alkaline Phosphatase: Recombinant human protein expressed in a mouse myeloma cell line
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Usage Statement
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For Research Use Only. Not for use in diagnostic procedures.
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Storage Statement(s)
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Please refer to the product insert for the storage conditions of individual kit components.
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Storage Condition
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Multi-Component
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Schedule B Code
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3002.15.0100
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Product Inserts
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Datasheets
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SDS
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Blocker A
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Diluent 10, Diluent 11, Diluent 12, Diluent 13, Diluent 15, Diluent 16 and Diluent 17
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Diluent 2, Diluent 3, Diluent 5, Diluent 7 and Diluent 8
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Diluent 50, Diluent 56, Diluent 61, Diluent 100, and Diluent 101
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MSD Calibrators and Controls
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Phosphate Buffer (5x)
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Read Buffer T (4x), Read Buffer S (4x) and Read Buffer S (1x)
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Title
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Journal
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Year
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Development of a multi-biomarker disease activity test for rheumatoid arthritis.
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First missense mutation in the SOST gene causing sclerosteosis by loss of sclerostin function.
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Serum correlates of the placebo effect in irritable bowel syndrome.
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Sex and ethnic differences in 47 candidate proteomic markers of cardiovascular disease: the mayo clinic proteomic markers of arteriosclerosis study.
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