The V-PLEX COVID-19 Respiratory Panel 2 (ACE2) Kit is a multiplex neutralization assay that measures the antibodies capable of blocking the binding of angiotensin-converting enzyme 2 (ACE2) to the SARS-CoV-2 Spike and RBD antigens. The Panel serves as a high-throughput alternative to traditional neutralization assays. It includes 15 important antigens related to SARS-CoV-2, SARS-1, circulating Coronaviruses, and other respiratory diseases: HCoV-229E Spike, Flu A/Hong Kong H3, Flu A/Michigan H1, Flu A/Shanghai H7, Flu B/Brisbane HA, Flu B/Phuket HA, HCoV-HKU1 Spike, HCoV-OC43 Spike, HCoV-NL63 Spike, SARS-CoV-1 Spike, SARS-CoV-2 N, SARS-CoV-2 S1 NTD, SARS-CoV-2 S1 RBD, SARS-CoV-2 Spike, and RSV Pre-Fusion F.