VCAM-1

Vascular Adhesion Molecule-1 (VCAM-1/CD106) is a transmembrane protein expressed by activated endothelial cells, neurons, smooth muscle cells, fibroblasts, and macrophages. VCAM-1 expression is induced by IL-1β, IL-4, TNF-α, and IFN-γ. VCAM-1 binds to leukocyte integrins VLA-4 and α4β7, thereby mediating attachment of leukocytes to the vascular endothelium and extravasation of immune cells from vessels to site of inflammation. VCAM-1 binding may promote monocyte adhesion and accumulations on the vessel wall at sites that are prone to developing atherosclerotic lesions. Soluble VCAM-1 is also present in plasma and cerebrospinal fluid at variable levels which may lead to a variety of pathological conditions. Other roles proposed for VCAM-1 include the regulation of osteoclastogenesis via a cell-to-cell contact mechanism and the induction of sickle cell adherence to vascular endothelial cells during hypoxemia.

 

VCAM-1 Singleplex Products

Our VCAM-1 immunoassays provide fast, accurate, reproducible, and highly sensitive measurements of VCAM-1. MSD’s MULTI-ARRAY technology uses simple protocols, requires minimal sample, and quantifies analyte concentration over a wide dynamic range.

 

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