Sclerostin

Sclerostin, the product of the SOST gene, is a secreted glycoprotein produced by osteocytes. Sclerostin is expressed highly in bone, cartilage, kidney, and liver. Sclerostin is an important regulator of bone remodeling and homeostasis. Sclerostin has been shown to bind to Wnt coreceptor LRP5/6 inhibiting Wnt signaling which plays a key role in the regulation of bone formation. Sclerostin may also promote apoptosis of bone cells, further inhibiting bone growth. Mutations of sclerostin are associated with sclerosing bone dysplasia: sclerosteosis and van Buchen disease.

 

Sclerostin Singleplex Products

Our Sclerostin immunoassays provide fast, accurate, reproducible, and highly sensitive measurements of Sclerostin. MSD’s MULTI-ARRAY technology uses simple protocols, requires minimal sample, and quantifies analyte concentration over a wide dynamic range.

 

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Sclerostin Multiplex Products

Our multiplex panels let you process up to 10 analytes simultaneously in each well of a MULTI-SPOT microplate. They provide the same outstanding performance as our singleplex immmunoassays while saving money, sample, and time.

 

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